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《Acta Academiae Medicinae Weifang》 2006-03
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A Study on the Relationship between the Cell Proliferation and Apoptosis in the Kidey of Diabetic Mice

YUE Bing-de,GUAN Ying-jun,SUN Xiu-ning,GAO Hai-ling (Department of Histology and Embryology,Weifang Medical College,Weifang 261041,China)  
Objective To observe the relationship between the celluar proliferation and apoptosis in the kidey of the diabetic mice in order to investigate the mechanism of diabetes nephropathy.Methods The male Balb/c mice were used to induce diabetic model by intraperitoneal injection of STZ.Observe the early morphological changes of kidey by means of electron microscope.The protein of PCNA,Bax and Bcl-2 in the kidey of diabetic mice were detected by using the immunohistochemical method.Results ①Under the electron microscope,the foot process of the visceral epithelial cells confluenced and the glomerular mesangium became broader at the 2nd and 4th week.②The number of PCNA masculine cell was most on the 3rd day.From the 1st to 4th week,it was gradually decreased.On the 3rd day,the level of Bax was higher and the level of Bcl-2 was lower than that in control group.From the 1st to 4th week,Bax was gradually decreased and reached lest at the 4th week,while Bcl-2 was gradually increased and reached highest at the 4th week.On the 3rd day the ratio of Bax/Bcl-2 was largest.From the 1st to 4th week,the ratio was gradually decreased and reached lest at the 4th week.Conclusions In the early stage of diabetes nephropathy,the expression of PCNA and the ratio of Bax/Bcl-2 were decreased in the cell of the kidey,which suggests that they played a key role in the diabetes nephropathy.
【Fund】: 山东省自然科学基金(课题编号:Y97C05041)
【CateGory Index】: R587.1
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