THE SCAVENGING ACTIVITIES OF TGM AND TGP ON FREE RADICALS
Gao Benbo; Dai Liming; Xu Shuyun(Institute of Natural Drugs 261042)
The models of simplified O2-generating system, OH·-generating system and oxidative hemolysis induced by hydrogen peroxide were used to study the O2,OH·scavenging activity and inhibitory effects on oxidative hemolysis of total glucosides of Moutan Corter(TGM) and total Glucosides of Paeony Lactiflora (TOP) in this paper.The results shows that TGM and TGP can scavenge O2 and OH.; IC50of scavenging O2 are 2.31 and 2.64mg/L respectively, IC50 of scavenging OH are 25.69 and 117.96mg/L respectively. The IC50 of inhibiting oxidative hemolysis are 0.94 and 1.41mg/L respectively. The results suggest that TGM and TGP have the capacity to scavenge O2 and OH·,and can inhibit oxidative hemolysis induced by H202. The radical scavenging activity of TGM,in comparison with that of TGP,was more effective.
【CateGory Index】： R285.5