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《Journal of Mudanjiang Medical College》 2008-03
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EFFECTS OF TOTAL ASTRAGALOSIDES ON PROLIFERATION AND APOPTOSIS OF HUMAN LUNG CANCER CELL LINE A549

Niu Yan etal (Tianli Medicine Limited Company of Mudanjaing,Mudanjaing Heilongjiang 157000)  
Objective:To observe the effect of Total Astragalosides (TA) on proliferation of human lung cancer cell line A549.Method:Using cell culture,MTT assay,DNA agarose gel electrophoresis and flow cytometry to observe the effect of TA on proliferation of human lung cancer cell line A549.Result:TA suppressed the growth of A549 cells markedly and induced apoptosis in a dose and time dependent manner.The treated cells exhibited obvious apoptosis.The characteristic ladder-like DNA fragment appeared in the cells.Conclusions:TA can inhibit the proliferation of human lung cancer cell A549 in vitro.The effect is dose and time dependency.It can also induced apoptosis that may be related to arresting cell cycle at G1 phase by TA.
【CateGory Index】: R734.2
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