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《Journal of Modern Urology》 2009-06
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Correlations of matrix metalloproteinase content with invasion and metastasis of the transitional cell carcinoma of bladder

ZHU Feng1,ZHANG Yan2,ZHANG Hui-qing1,ZHANG Ying-jie1(1.Department of Urology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100;2.Function Laboratory,Science and Technology Agency of Xinxiang Medical University,Xinxiang 453001,China)  
Objective To investgate the correlations of serum matrix metalloptoteinase-2,-9(MMP-2,MMP-9) contents in the transitional cell carcinoma of bladder(TCCB) with tumor invasion and metastasis.Methods Serum MMP-2 and MMP-9 contents were detected in 46 patients with transitional cell carcinoma of bladder and 18 healthy controls by enzyme-linked immunosorbent assay(ELISA).Results Serum MMP-2 and MMP-9 contents were significantly elevated in cancer samples compared with normol control group(P0.000),serum MMP-2 and MMP-9 contents had significant difference along with clinical stages elevation(P0.000).MMP-2 and MMP-9 contents in stage Ⅱ and stage Ⅲ were obviously higher than in stage Ⅰ(P0.000),but there was no significant relationship between stage Ⅲ and stage Ⅱ(P0.05).Conclusion MMPs was closely related with the occurrence,development and invasion and metastasis of urinary bladder transitional cell cancer.Serological determination of MMPs could be used as one of the prognostic indicators in the transitional cell carcinoma of bladder.
【CateGory Index】: R737.14
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 KONG Ling-Ling,WANG Xue-Chun,CUI Wen,WANG Xu,YANG Qing-Yuan,SONG Xi-Yuan,JIANG Xiao-Gang,YAN Chun-Yan Department of Pathology,Jining Medical College,Jining 272013,China;Expression of MMP-9 and its clinical significance in cervical squamous carcinoma[J];Journal of the Fourth Military Medical University;2008-03
2 Xue Hongpeng, Lu Yixia, Heilongjiang Provincial Hospital for Digestive Diseases, Ha'erbing, 150000 Zhou Zhaohai, The First Hospital of Mudanjiang, Heilongjiang Province, 157000;The Correlation between MMP-2 expression and Gastric Cancer Invasion and Metastasis[J];Chinese Medical Record;2008-01
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 LI Hui-mei, XIAO Wei, CAO Ai-fang, et al.;Expression of Serum Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Lung Cancer[J];Journal of Oncology;2008-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 FENG Guosheng , TAN Yuquan. Department of General Surgery, Railway General Hospital of Beijing,Beijing 100038, China.;Expression and significance of MMP_2 and type Ⅳ collagen in gastric cancer[J];Chiese Journal of Surgery;2000-10
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