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《Chinese Journal of Aesthetic Medicine》 2002-01
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METALLOTHION CAN REINFORTH THE DELAYED PROTECTION THROUGH PRECONDITION OF FLAP ISCHEMIA

GUO Jie,JIANG Hong chi,WANG Shu jie,et al Department of Plastic surgery,the Second Hospital of Haerbin Medical University,(HaOerbin 150086)  
We try to study if matallothion participates the process of protecting the flaps which has been preconditioned with ischemia Methods:On the models of island flaps of musculus latissmus dosi of pigs and cultured myocyte,both have been preconditioned respectively by ischemia and anoxia,we have detected the change of the content of MT instantly,12 hours later and 24 hours later then we have observed the protection from damage of again disposition of ischemia/reperfus of anoxia/reoxygenation(from the area of flap necrosis,servival rate of cells,the quantity of LDH discharged and the content of MDA in the cells) and what would be with the delayed protection if the MT was inhibited by PD 098059 Results:The content of MT,12 hours later in myocyte and 24 hours in myocyte and flap tissue from being conditioned,increased obviously Compared with non conditioned flap tissue or myocyte,the necrosis areas of the preconditioned flaps were smaller,the activity increases of the hematoplasmas LDH were lower,the servival rate of myocyte is higher,the content of cell MDA and the quantity of discharged LDH is less When the generation of MT was inhibited by PD 098059,we observed that the DP of PC was removed and the above quotas of damage of the flaps were close to those of the group of simple I/R or A/R(P0 05)which was preconditioned 24 hours ago Conclusion:①The flaps and myocytes which are preconditioned 24 hours ago have protection from again damage of I/R or A/R ②MT is involved in DP in the preconditionde flaps or myocytes
【Fund】: 黑龙江省社会发展基金资助项目 (G99C 2 0 10 2 )
【CateGory Index】: R622
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