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《Chinese Journal of Aesthetic Medicine》 2015-16
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Effect of glycyrrhizin on chronic urticaria patients in IL-4,IL-8,IL-17 and IL-22

ZHANG Yu-gang;Department of Dermatology,Chinese Medicine Hospital of Fengrun District;  
Objective Based on measurement of chronic urticaria patients serum IL-4 and IL-8,IL-17 and IL-22 before and after 18 beta glycyrrhizin in the treatment of glycyrrhizin mechanism on treating chronic urticaria. Methods The levels of serum IL-22,IL-8,IL-17 and IL-4 in 20 cases of chronic urticaria were detectedbyblot Westernassayand 20 casesofhealthycontrols. Results Inpatientswithchronicurticaria by 18 beta glycyrrhizin treatment IL and serum concentrations of IL- 4(22.75 ± 6.87pg/ml),IL- 8concentration(20.26 ± 4.52pg/ml),IL- 17 concentration(24.62 ± 7.28pg/ml)and IL- 22 concentration(23.26±9.04pg/ml),higher than the healthy control group(P0.05).After the treatment, concentration of IL-4 was(14.44±4.29pg/ml),IL-8 concentration(12.24±3.32pg/ml),IL-17 concentration(13.32±1.61pg/ml),IL-22 concentration(14.32±1.59pg/ml),treatment significantly decreased(P0.05),and healthy control difference no statistical significance(P0.05). Conclusion The serum of patients with chronic urticaria of IL-4 and IL-8,IL-17 and IL-22 levels different from normal,suggesting that chronic urticaria patients with thedisorderofimmunefunctioninthebody;and 18 betaglycyrrhizicacidglycosidestreatmentofserum IL-4 and IL-8,IL-17 and IL-22 reduced obviously,18 beta glycyrrhizin tips may through the influence of T helpercellrelatedcytokinestoplayaroleintreatmentofchronicurticaria.
【CateGory Index】: R758.24
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