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《IMMUNOLOGICAL JOURNAL》 2000-03
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Effect of astragalus polysaccharin(APS)on lymphocyte-endothelium adhesion and the molecular mechanism

HAO Yu,QIU Quanying,WU Jun (Department of Immunology,Beijing University of Chinese Medicine,Beijing 100029,China)  
ObjectiveTo investigate the effect of APS on lymphocyteendothelium adhesion and cell adhesion molecules(CAMs)Methods Based on the model of human umbilical vein endothelial cell(HUVEC),this study adopted Rose Bengal Stain,cell ELISA,immunocytochemistry techniques to investigate the effect of APS on lymphocyteendothelium adhesion and the molecular mechanismResults Incubation of HUVEC with APS markedly enhanced HUVEC adherence for lymphocyte and APS had synergism with IL1 and TNFThe main molecular mechanism is that APS upregulate the expression of ICAM1 on the HUVECThe lymphocyte treated with APS did not show increase in their adherence to HUVEC,and had no upregulation of CD18 expressionConclusion It is one of the mechanisms of immunopotentiation of APS that it promote lymphocyteendothelium adhesion by upregulating the CAMs expression to promote lymphocyte recirculation [
【Key Words】： lymphocyte HUVEC adhesion molecule astragalus polysaccharin(APS)
【Fund】： 国家自然科学基金!(39870949);; 教委博士点基金!(9858)资助项目
【CateGory Index】： R285
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