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《Immunological Journal》 2005-03
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Advances in the research on biological function of NK cell receptor KIR

ZHANG Yuan-yuan, WANG Qing-qing (Institute of Immunology, Zhejiang University, Hangzhou 310031, China)  
The killer Ig-like receptors (KIRs), which are expressed on natural killer cells and some populations of T cells, belong to the immunoglobulin superfamily. KIRs, including inhibitory and activating receptors, regulate the activity of natural killer cells through recognizing the HLA-I molecules expressed on target cells, thus play importance roles in pregnancy, hematopoietic stem cell transplantation, and development of autoimmune disease. Here we summarize recent advances in the research of killer Ig-like receptors, including the structure and biological function of KIRs and the ligand specificities of KIR molecules.
【Fund】: 国家自然科学基金资助项目(30328011)
【CateGory Index】: R392
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