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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2017-19
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Study on Acute Toxicity of Xuezhitai Dispersible Tablets on Rats

ZHOU Cuilan;CHEN Qiyou;LI Jihong;PENG Yuangui;HUANG Dasen;ZHANG Guangming;Guangzhou Yipinhong pharmaceutical Co.,LTD;Hubei Province Drug Safety Evaluation Center;Changsha Institute of Innovation in Traditional Chinese Medicine;  
Objective To investigate the acute toxicity to rats of a oral single-dose of Xuezhitai dispersible tablets,reveal the potential toxicity target organs preliminaryly,and provide references for the dose-design of subsequent toxicity tests and clinical trials. Methods 40 rats were randomly divided into the test group and the vehicle control group,20 rats in each group male and female half. Use the maximum tolerance method,the solvent is 0. 5 % carboxymethyl cellulose sodium,5000 mg/kg a time by intragastric administration. Give a continuous observation of 6 h and 2 records on the first day of administration,then observe 1 time daily for 14 days. The indicators include rats' physical characteristics,body weight,food intake and water intake and tissue biopsies. Results The weights of male rats in test group are significantly lower than the control group( P 0. 05) on d1,d3,d5 post-dose. And weight gains are also significantly lower than the control group( P 0. 05). Food-intakes are significantly lower than the control group( P 0. 05) on the second day of dosing. Other indicators are no significant different( P 0. 05). Conclusion The maximum tolerance is greater than 5000 mg/kg and the toxicity is shown to inhibit weight gain of a oral single-dose of Xuezhitai dispersible tablets.
【Fund】: 广东省重大科技专项(NO:2012A080204008);; 广州市重大科技专项(NO:201300000044)
【CateGory Index】: R285.5
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