Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Nanchang University(Natural Science)》 2006-03
Add to Favorite Get Latest Update

Simul Taneous Spectrophotometric Determination of Metronidazole,Fenbufen and Ketoprofen Using Multivariate Calibration Method

GE Cheng-xiang,NI Yong-nian(Department of Chemistry,Nanchang University,Nanchang 330047,China)  
Metronidazole Fenbufen and Ketoprofen have absorption property in ultraviolet zone,and their absorption spectra are overlapping.Generally,they can not be determined individually by spectrophotometry without prior separation.In this paper,the chemometrics multivariate calibration method was applied to the simultaneous determination of these three compounds in a potassium dihydrogen phosphate-sodium hydrogen phosphate buffer solution(pH7.0),and the analytical results was compared with classical least squares(CLS),principal components regression(PCR) and partial least squares(PLS).The linear ranges of metronidazole fenbufen and ketoprofen are 0.8~10.0,0.2~6.0 and 1.0~16.0 μg/mL,respectively.The proposed method was successfully applied to the analysis of some medicine products with satisfied results.
【CateGory Index】: TQ460.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved