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《CHINESE JOURNAL OF STEREOTACTIC AND FUNCTIONAL NEUROSURGERY》 1999-02
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Experimental study of Nao Gong Fu De in treatmint of Parkinson's disease

Lv Shengqing,Zhang Kecheng,Cai Wenqin,He Jiaquan,Liu Shiyong Department of Neurosurgery,Xinqiao Hospital,Third Military Medical College,Chongqing 400037 * Department of Histology and Embryology,Third Military Medical College,Chongqing 400038  
Objective:To investigate the therapeutic effect of Nao Gong Fu De (NGFD)in Parkinson's disease (PD). Methods:The Parkinson's disease models were creaed by unilateral substantia nigra injection of neurotoxin 6-hydroxydopamine (6-OHDA) using stereotactic method,which can destroy selectively the catecholaminergic neurons and their endings.Nao Gong Fu De were injected into the stomachs of the models for 3 weeks,and then,the rotational behavior of PD rats was observed at the different time.The rats were killed three months later,and the quantities of dopamine (DA) in the striatums were evalusted by high performance liquid chromatography with electrochemical detection (HPLC-EC).Results:The rotational behavior of PD rats in treatment group reduced significantly after 2 weeks,1 month、2、3 months.The quantities of DA in the striatums increased much more than the group without NGFD.Conclusions:Nao Gong Fu De is an effective Chinese medicine for Parkinson's disease.
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