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《Journal of Naijing University (Natural Sciences)》 2001-05
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Applications of Neural Network Ensemble in Lung Cancer Cell Identification

Jiang Yuan, Zhou Zhihua, Xie Qi, Chen Zhaoqian(State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, 210093, China)  
Lung cancer is one of the most deathful diseases in the world. In general, 80% of the patients were in the terminal stages when their illnesses were diagnosed as lung cancer. However, research reveals that if their illnesses can be diagnosed in early stages, the 5 year survival rate of the patients can be improved to about 40%. Therefore trying to find out the canceration at the earliest opportunity is a very pressing task. Until now, most work on computer aided lung cancer diagnosis exploit X ray chest images or CT images. Some exploit bronchoscopy. But the most reliable process of diagnosing lung cancer, i.e. pathologic diagnosis, has not been utilized. In this paper, an early stage diagnosis system LCDS for lung cancer is presented. LCDS employs digital image processing and neural network techniques to analyze the cell images of puncturing specimen from the patients, and uses the proof of the existence of cancer cells to perform diagnosis. Therefore the pathologic techniques are tightly combined with computer techniques. LCDS employs CCD and image acquisitor to get cell images of high quality that are gradually processed by cleaning, smoothing, sharpening, segmenting and filtering procedures. Then the morphological features and colorimetric features are extracted, which are fed to a neural network ensemble to identify cancer cells. In this paper, a specific two layer ensemble architecture is devised to accomplish this task. The neural model used here is FTART2, which is a fast neural classifier that combines the advantages of the adaptive resonance theory and the field theory. The individual networks in the ensemble are generated by Bagging that is capable of improving the predictive accuracy of unsteady learning algorithms such as neural networks and decision trees. The individual networks in the first layer ensemble are combined by a strategy named full voting, which is proposed in this paper. Only when all the individual networks admit that there is no cancer cell, the output of full voting is "normal cell"; otherwise the output is "may be cancer cell". The individual networks in the second layer ensemble are combined by plurality voting, which is a popular way of ensembling multiple classifiers. Experiments show that the overall error identification rate of the specific neural network ensemble of LCDS system is quite low. What is more important is that its error identification rate of identifying normal cancer cells is so low that the probability of misdiagnosing lung cancer patients to be healthy persons is greatly decreased.
【Fund】: 国家自然科学基金 (6 9875 0 0 6 );; 江苏省自然科学基金 (BK990 36 )
【CateGory Index】: TP183
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【References】
Chinese Journal Full-text Database 10 Hits
1 LAI Fangmin1 LI Bin1 TIAN Lianfang1 CHEN Ping21 College of Automation Science and Engineering,South China University of Technology,Guangzhou 510640; 2 Nuclear Medicine Department,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120;A Method of Segmenting Lung Tumor Based on SUV and Active Shape Model[J];Beijing Biomedical Engineering;2009-03
2 DING Jie, WEI Min-wen, DAI Jie, CHEN Qing-qi, ZHANG Jin-hua, LIU Jian-ping, WU Zhi-jian, LU Qiang, QIAO Hong (Nanjing Automation Research Institute, Nanjing 210003, China) (Hunan Electric Power Co, Changsha 410076, China) (The PLA's Polytechnic University, Nanjing 211101, China);Application of Warehouse & Data Mining Technology to Hunan Reservoir Scheduling[J];Dam Observation and Geotechnical Tests;2005-03
3 LIU Qiong sun 1, HE Li qing 2 (1.College of Mathmatics and Physics Chongqing Unviersity,Chongqing 400044,China; 2. College of Automation,Chongqing University, Chongqing 400044, China);Diagnosis Model Based Neutral-network in Galactophore Cancer Cell Identification[J];Journal of Chongqing University(Natural Science Edition);2003-04
4 XIE Hua.XIA Shun-ren.ZHANG Zan-chao.Key Laboratory of Biomedical Engineering of Ministry of Education.Zhejiang University.Hangzhou 310027.China;Advances in fusion of multiple classifiers for medical image recognition[J];International Journal of Biomedical Engineering;2006-03
5 ZHANG Zhen,WANG Wen-fa(Institute of Computer Science,Yan’an University,Yan’an 716000,Shaanxi China);Application of Artificial Intelligence in Mankind Study[J];Journal of Jishou University(Natural Sciences Edition);2006-01
6 YU Shan-xian (Zhejiang Meteorological Research Institute,Hangzhou 310004,China);Some Problems in Neural Network and Prediction Ensemble and its Counter Measure[J];Bulletin of Science and Technology;2006-02
7 Yang Yü_Bin, Li Ning, Chen Shi_Fu, Chen Zhao_Qian, 210093 China);Intelligent Lung Cancer Identification Based on Image Features[J];Journal of Nanjing University (Natural Sciences);2003-02
8 Wang Chong-Jun , Yu Wen-Di, Chen Zhao-Qian , Xie Jun-Yuan (State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093, China);A BP Neural Network Algorithm Based on Genetic Algorithms and Its Application[J];Journal of Nanjing University (Natural Sciences);2003-05
9 Wang Zheng-Qun~(1,2),Chen Shi-Fu~1,Chen Zhao-Qian~1 (1.State Key Laboratory for Novel software Technology,Nanjing University,Nanjing,210093,China;2.School of Information Engineering,Yangzhou University,Yangzhou,225009,China)[KH*2/3D];Neural Network Ensemble Based on Fuzzy Partition[J];Journal of Nanjing University(Natural Sciences);2006-01
10 Liu Xu-Ying~1,Wu Jian-Xin~2,Zhou Zhi-Hua~1(1.National Laboratory for Novel Software Technology,Nanjing University,Nanjing,210093,China;2.College of Computing,Georgia Institute of Technology,Atlanta,30332-0280,USA);A Cascade-based Classification Method for Class-imbalanced Data[J];Journal of Nanjing University(Natural Sciences);2006-02
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Zhi hua, CHEN Zhao qian, CHEN Shi fu (State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, 210093,China);RESEARCH OF FIELD THEORY BASED ADAPTIVE RESONANCE NEURAL NETWORK[J];JOURNAL OF NAIJING UNIVERSITY (NATURAL SCIENCES);2000-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHAO Dong, ZHOU Zhi Hua, and CHEN Zhao Qian (State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093);AN ADAPTIVE FAULT TOLERANT NEURAL NETWORK CLASSIFIER[J];Journal of Computer Research and Development;2001-03
2 ZHOU Zhi-Hua, LI Ning, YANG Yu-Bin, and CHEN Shi-Fu (National Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093);EARLY STAGE LUNG CANCER DIAGNOSIS BASED ON NEURAL NETWORK ENSEMBLE[J];Journal of Computer Research and Development;2002-10
3 Liu Yue Liu Hui Li Yuan Zhang Bofeng Wu Gengfeng(School of Computer Engineering & Science,Shanghai University,Shanghai 200072);Impulse Force Based ART Network with GA Optimization and its Application to Earthquake Prediction[J];Computer Engineering and Applications;2005-05
4 Xie Hua1 Xia Shunren1 Gao Guangjin2 1(The Key Laboratory of Biomedical Engineering,Ministry of Education,Hangzhou 310027) 2(Dept. of Computer Engineering,Shandong College of Information Technology,Weifang 261000);Study of Marrow Cell Recognition Based on Multiple Classifier Fusion[J];Computer Engineering and Applications;2005-27
5 LU Xin Quan LI Ning CHEN Shi Fu (State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093);Research on Application of Morphological, Color Features and Neural Network to the Recognition of Lung Cancer Cells[J];Journal of Computer Aided Design & Computer Graphics;2001-01
6 ZHOU Zhi Hua CHEN Zhao Qian SHAO Dong CHEN Shi Fu(State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093);A Novel Adaptive Neural Network Regression Estimate Algorithm[J];CHINESE JOURNAL OF COMPUTERS;2000-06
7 ZHOU Zhi-Hua GE Xiang CHEN Zhao-Qian (National Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093);Constructive Hybrid Decision Tree[J];Chinese Journal of Computers;2001-10
8 YAN You- biao,CHEN Yuan- yan (College of Mathematics & Computer Science,Guangxi Normal University,Guilin Guangxi 541004,China);A Survey on Machine Learning and Its Main Strategy[J];Application Research of Computers;2004-07
9 Wu Mingqiang~1,Li Jihong~1, Cao Aidong~2,Shi Hui~2 (1.The 2nd Artillery,Beijing100000,China; 2.Beijing Aerospace Measurement&Control Technology Development Co.,Beijing100830,China);Study on Combined Intelligent Inference Technology for Fault Diagnosis Expert System[J];Computer Automated Measurement & Control;2004-10
10 Yin Xuri, Zhou Zhihua, Chen Shifu (State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, 210093);RESEARCH ON MULTI REASONING METHOD IN POWER TRANSFORMER RUNNING STATE DETECTION[J];Pattern Recognition and Artificial Intelligence;2000-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Pin -zheng,WAN Sui -reng(Southeast University,Department o f Biomedical Engineer ,Nan Jing 210096,China);The Algorithm and Implementation of Applying Wavelet Packets to Obtain the Leucocyte's Nuclear Edge[J];Journal of Anhui Tv University;2002-01
2 SUN Lirong, LI Xuerong, PANG Xiuying, et al\ Department of Pediatrics, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003\;;THE VARIATION OF ERYTHROCYTE INDEX AND ITS SIGNIFICANCE DURING INHIBITORY STAGE OF BONE MARROW IN CHILDTEN WITH ACUTE LEUKEMIA[J];Acta Acadimae Medicinae Qingdao;2002-03
3 ZHOU Hao, LI Tianmu, WEI Hong. Department of Information and Electronics, Yunnan University,Yunnan 650091;Extraction of Image Boundary of Blood Corpuscle Based on Mathematical Morphology[J];Beijing Biomedical Engineering;2002-02
4 LI Xin quan,FAN Wei,YAN An wen,et al Affiliated Hospital,Academy of Military Medical Sciences(Beijing,100039);LEUKAPHERESIS AND TELOMERASE TEST IN ACUTE LEUKEMIC PATIENTS WITH HYPERLEUKOCYTOSIS[J];Journal of Leukemia;2000-06
5 SUN Dan 1, ZHANG Xiu-yan 2 (1.School of Information Science, Tianjin Business College, Tianjin 300122, China; 2.College of Business, Jilin University, Changchun 130012, China);Forecast model for stock market based on artificial neural networks[J];Journal of Changchun Post and Telecommunication Institute;2002-04
6 ZHOU Qi-ming~1,WANG Miao~2,REN Hong~1(1.Faculty of Construction Management & Real Estate, Chongqing University. Chongqing 400045, China; 2.Futian Audit Buarea of Shenzhen City, Shenzhen 518048, China);The research of application of constructional engineering cost estimation by neural network ensemble[J];Journal of Chongqing Jiaotong University;2005-04
7 LI Min 1,ZHOU Jie zhong 1,LI Jun ping 1,LIANG Jian wu 2 (1. Research Department,Changsha Railway University,Changsha 410075,China;2. Center for Modern Education Approch, Changsha Railway University,Changsha 410075,China);Predicting Securities Market in Shanghai and Shenzhen by ARMA Model[J];JOURNAL OF CHANGSHA RAILWAY UNIVERSITY;2000-01
8 Li Jingjiao,Sun Jie,Zhang Li,Yao Tianshun (School of Information Science and Engineering,NEU, Shenyang 110006);Hybrid Model of Hidden Markov Models and a Self Organizing Neural Network Model in Speech Recognition[J];JOURNAL OF NORTHEASTERN UNIVERSITY;1999-02
9 Ding Jie,L i H oujun,Zhou H aisong,H uang Chunlei,Zhao Yu Nanjing Automation Research Institute,Nanjing2 10 0 0 3,China;DESIGN OF DECISION SUPPORT SYSTEM FOR HYDROPOWER DISPATCHING[J];Dam Observation and Geotechnical Tests;2002-01
10 Ding Jie (Nanjing Automation Research Institute, Nanjing 210003, China);RESEARCH AND CONSTRUCTION OF DIGITALIZED RESERVOIR OPERATION SYSTEM[J];Dam Observation and Geotechnical Tests;2004-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 JIANG Zhong-shan1,SONG Chao2,ZHU Fei-xiang2,SI Wei-chao2(1.Dept.of Control Engineering,Naval Aeronautical Engineering Institute,Yantai 264001,China;2.No.4 Brigade of Postgraduate,Naval Aeronautical Engineering Institute,Yantai 264001,China);Application of Optimized BP Neural Network Based on Genetic Algorithm in PID Control of Speed[J];Ordnance Industry Automation;2009-03
2 LI Cailin1,2,XU Huijun1,WANG Jinwen1(1.Huazhong University of Science and Technology,Wuhan 430074,China)(2.Guilin University of Electronic Technology,Guilin 541004,China);Application of Data Mining to Runoff Prediction[J];Hydropower Automation and Dam Monitoring;2007-02
3 ZHOU Haison1,XUE Shengning1,LI Desheng2 (1.Nanjing Automation Research Institute,Nanjing 210003,China) (2.Jiangyin Water Conservancy Bureau,Jiangyin 214400,China);Discussion on Multi-schemes Replacing Multi-instances in Oracle[J];Hydropower Automation and Dam Monitoring;2007-03
4 ZHOU Haisong1,ZHANG Jian2,WU Zhijian3,HU Xuejiao2(1.State Grid Electric Power Research Institute,Nanjing 210003,China;2.Bureau of Taihu Lake Basin,Shanghai 200434,China;3.The PLA University of Science and Technology,Nanjing 210000,China);Application of OLAP to Distance Hydrological Measuring System of Taihu Lake Basin[J];Hydropower Automation and Dam Monitoring;2009-01
5 ;Plan on Diagnosis of Breast Cancer based on Gene Expression Programming[J];Computer Development & Applications;2005-12
6 ZHANG Fu-ping,LI Tang-jun,YANG Lei;Analysis of Gas Explosion Cause in Heading Face Based on Optimized Fuzzy Petri Network of Genetic Algorithm[J];Mining Safety & Environmental Protection;2008-02
7 SHANG Jie1,ZHU Zhan-li21.Anhui Trade Professional Technology Institute,Huainan 232001;2.Xi′an Petroleum University,Xi'an 710065;APPLICATION OF GENETIC ALGORITHMS NEURAL NETWORKS IN PREDICTING CORROSION RATE OF CARBON STEEL[J];Corrosion Science and Protection Technology;2007-03
8 QI Chang-hai1 ZHENG Zhi-yong1 LIU Bing-han2 YAO Li-qing1 WU Yi-man3 ZENG Ling1 (1.Department of Pathology,Fuzhou General Hospital of Nanjing Command,Fuzhou 350025,China. 2.College of Mathematics and Computer Science,Fuzhou University,Fuzhou 350002. 3.Department of Modern Medicine,Fujian College of Traditional Chinese Medicine,Fuzhou 350003.);Image Analysis Research on Morphological Parameters of Nucleus of Lymphoid Follicular Cells and Centroblastic Lymphoma Cells[J];Journal of Fuzhou General Hospital;2008-S1
9 ZHANG Zhen,LIU Fen(Institute of Computer Science,Yan'an University,Yan'an 716000,China);Scheme exploration for creative mind based on artificial intelligence[J];Journal of Guangzhou University(Natural Science Edition);2009-01
10 Zhao Li(Harbin Normal University)Li Tianshu(Northeast Forestry University)Liu Yulei(Harbin Normal University);RESEARCH OF MACHINE-LEARNING BASED ON SUPPORT VECTOR MACHINE[J];Natural Science Journal of Harbin Normal University;2008-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ;Review of Adaptive Resonance Theory[J];Computer Science;1999-04
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