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《J0urnal of Nanjing Military Medical College》 2003-04
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Mornitoring drug resistance of meticillin-resistant Staphylococcus aureus

XIONG Jian-wen, PEI Yun, FENG Rui-xiang, LI Ya-shu, YANG Cheng-fang (Department of Clinical Laboratories, the 414th Hospital of PLA, Nanjing, Jiangsu 210015,China)  
Objective: To mornitor the bacterial drug resistance of the clinical isolated meticillin-resistant Staphylococcus (MRS) and to explore the treatment strategy of the infection caused by resistant strains. Methods: Phenotypic surveillance test was used to detect MRS in 152 strains of Staphylococcus spp isolated from clinical patients; Kirby-Bauer agar diffusion method was used to judge the drug sensitivity. Results: Seventy-nine MRS were isolated and the detectable rate was 51.97%. Among them Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRCNS) was 60.00% and 41.79%, respectively. MRS strains had lower drug resistance to vancomycin, rifampin and aminogbycoside, however, they had higher drug resistance to other antibiotics. Apart from the higher drug resistance to penicillin, the drug resistant rate of meticillin sensitive Staphylococcus (MSS) was remarkablely lower than MRS strains. Conclusion; MRS has multi-drug resistance, and the long time bacteria drug resistance should be mornitored; Vancomycin is the first choice for the treatment of severe systemic infections caused by MRS strains.
【CateGory Index】: R446.5
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