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《Journal of Nanjing University of Science and Technology》 2014-01
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Determination and correlation of solubilities of ivermectin in alcohol and alcohol-water mixture

Xu Hongxia;Jiang Linkun;Wang Lisheng;Wuhai Institute,Inner Mongolia University of Technology;School of Chemical Engineering and Environment,Beijing Institute of Technology;  
In order to provide basic data of solvent selection and temperature control of purification in catalytic hydrogenation of avermectin to ivermectin process,the solubilities of ivermectin in methanol( 293. 15 ~333. 15 K),alcohol( 293. 15 ~ 343. 15 K),water-methanol mixture( 293. 15 ~ 333. 15 K),and water-alcohol mixture( 293. 15 ~ 343. 15 K) are experimentally determined by theequilibrium method. The experimental results are correlated with mathematic models such as polynomial empirical equation,the ideal solution equation,and Apelblat equation,respectively. The results show that the solubilities of ivermectin in two alcohol-water systems increase with the temperature; the solubility of ivermectin in the methanol-water solvent system decreases with the the increase of water content at the same temperature,and in the ethanol-water solvent system,the solubility of ivermectin in 85% ethanol solution reaches a maximum. Each of the equations describes the above systems successfully,the correlation coefficients are above 98%. The Apelblat equation is the best to correlate the solubility data. Results of experiments and correlations can be used for the crystallization procedure of ivermectin production.
【Fund】: 内蒙古自治区自然科学基金(NJC11311);; 中央财政支持重点建设项目(530201)
【CateGory Index】: O645.2
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