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《Journal of Nanjing Normal University(Natural Science Edition)》 2008-04
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Influence on Osseous Changes of Diabetic Rat by Lycopene

Pei Lingpeng(Institute of Chinese Traditonal Minority Medicine,Central Univeristy for Nationalties,Beijing 100081,China)  
Evaluation of the effects of lycopene on osseous change of diabetic rats induced by streptozotocin(STZ)injected at several low dosages were made.Injections of STZ for six weeks to set mode of the diabetic rats.They were randomly divided in four groups,including control group,diabetic model group,lycopene group and insulin-treated diabetic group,whose osseous routine parameters were tested and compared.Compared with control group,the bone mineral density(BMD),structural power parameters of bone,biological power parameters of bone,bone calcium,manganese,magnesium and the content of hydroxyproline in the diabetic model group were significantly decreased(P0.01).And the content of bone phosphorus,the activity of bone and serum alkaline phosphatase(ALP)were significantly raised(P0.01).Moreover,it is significantly different between lycopene group and diabetic model group in these parameters(P0.01).But the cured effect of insulin-treated diabetic group was better than the lycopene group.Lycopene can reduce the incidence of diabetes in rats induced by streptozotocin at several low dosages,and reform the osseous change of diabetic rat.
【Fund】: 国家自然科学基金(30171169)资助项目
【CateGory Index】: R587.1;R151
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