Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Southeast University(Medical Science Edition)》 2007-04
Add to Favorite Get Latest Update

Influence of radix salviae miltiorrhizae on the learning and memory and level of AChE and ChAT in hippocampus of status epilepticus juvenil rats

SUO Guo-ling1,TANG Hong-li1,2,WANG Xiu-li1(1.School of Clinical Medicine,Southeast University,Nanjing 210009,China;2.Department of Pediatrics,Institute of Clinical Medical Research,Nanjing 210009,China)  
Objective To establish status epilepticus(SE) animal model and investigate the influence of radix salviae miltiorrhizae(RSM) on the learning,memory and level of AChE and ChAT in hippocampus.Methods A juvenile rat model of SE was established by injection of pentylenetetrazole intraperitoneally.The rats were treated with radix salviae miltiorrhizae(RSM),phenobarbital(PB),respectively.The learning and memory were tested by Morris water maze after 7 days,level of AChE and ChAT in hippocampus was examined by homogenate colorimetric method.Results In PTZ group,the time for the rats to find the hiding flat were prolonged(P0.05),the time of target quadrant retention reduced(P0.01),the percentage of the effective searching strategy reduced(P0.01),level of AChE and ChAT in hippocampus of status epilepticus decreased(P0.01),both RSM and PB group improved learning and memory disorder after SE respectively.RSM group increased the level of AChE and ChAT after SE,PB group only increased the level of AChE.Conclusion SE can damage learning and memory of juvenil rats,AChE and ChAT may participate the process of the pathological and physiological change.RSM intervention may improve learning and memory of juvenil rats through repair choline system of hippocampus.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 6 Hits
1 TANG Yan,LI Xiang,WANG Li(Luzhou University of Medical Science,Luzhou 646000 China);The Influence of Noise on Learning and Memory in Rats and Cholinergic System in Hippocampus[J];Industrial Health and Occupational Diseases;2010-01
2 ZHU bai-ke1,WANG jing-jing2 1.Master of 2005 Grades in Hunan University of Traditional Chinese Medicine; 2.Hunan University of Traditional Chinese Medicine,Changsha,China,410007;Study Progress in the Anti-epilepsy Mechanism of Single TCM[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2008-07
3 Ma Xingrong,Sun Zhikun,Liu Yanru,Jia Yanjie,Zhang Boai Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan,China;Investigation of effects of atorvastatin on Aβ_(1-40)induced Alzheimer’s disease rat model[J];Chinese Journal of Practical Nervous Diseases;2013-12
4 WEN Chun-xiao,YAN Yu-xian;Effects of neurotransmitters on learning and memory[J];Acta Academiae Medicinae CPAF;2009-01
5 CHEN Mei-li, BAI Yu. Department of Neurology, Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200063, China;Relationship between Epilepsy and Cognition Dysfunction (review)[J];Chinese Journal of Rehabilitation Theory and Practice;2012-04
6 CHENG Shu-Zhen,WANG Li-Jun,LIU Heng,et al. Department of Biochemistry,College of Hebei Engineering University,Handan 056038,Hebei,China;Effect of Tongjingbushen complex prescription on acetylcholine esterase,choline acetyltransferase and acetylcholine in hippocampus of Alzheimer′s disease rat induced by aluminum[J];Chinese Journal of Gerontology;2012-21
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LOU yan,WANG Wei-ping~(*),WANG Xiao-peng,DUAN Rui-sheng,LI Pan,HUO Hui-yong,CHEN yong-mei(Department of Neurology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China);Changes in behavior and neuopeptide Y mRNA expression of sustain epileptic rats[J];Basic Medical Sciences and Clinics;2005-07
2 XU Ge-lin, HUANG Yuan-gui, MIAO Dan-min.(Department of Neurology, Xijing Hospital, Forth Military Medical University, Xi'an 710032, China);Effects of pre- and postnatal choline supplementation on cognition impairments induced by seizures[J];Journal of Apoplexy and Nervous Diseases;2003-02
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 WANG Wei-ping1, LOU Yan2, LI Pan1, DUAN Rui-sheng1, CHEN Wei-hua3 1Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China; 2Department of Pediatrics, 3Deparment of Clinical Laboratory, People's Hospital of Hebei Province, Shijiazhuang 050051, China;Changes in learning and memory functions in rats with status epilepticus and generalized nonconvulsive status epilepticus[J];Journal of Southern Medical University;2008-02
2 XIAO Zhao-yang~1,YIN Sheng-ming~2,PENG Yan~2,Y(U··) De-qin~2,GAO Xi~2,ZHAO Jie~2,ZHANG Wan-qin~(2*)(1.Department of Anesthesiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011;2.Department of Physiology,Dalian Medical University,Dalian 116027,China);Spontaneous recurrent seizure induced by KA damages spatial learning and memory as well as dopaminergic neurons in rats[J];Basic & Clinical Medicine;2006-11
3 WANG Pei,WANG Wei-ping,WANG Hai-xiang,LIU Rui-chun,WANG Xiao-peng,FAN Yue-hui,HU Hua-wei(Dept.of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China);Impaired spatial learning and decreased PSD-95 expression in hippocampus of pentylenetetrazol-kindled seizure of rats[J];Basic & Clinical Medicine;2007-11
4 ;The Effect of Status Epilepticus and Chronic Epilepsy on the Ability of Learning and Memory and Emotional Behavior in Rats[J];Journal of Brain and Nervous Diseases;2007-01
5 WANG Pei,WANG Bing,LIU Rui-chun,et al.Department of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Effect of Pentylenetetrazol-kindled Epilepsy on Learning and Memory and Expression of Postsynaptic Density 95 in Rats[J];Chinese General Practice;2008-03
6 LIN Shuang-feng, ZOU Yan-yan, LI Xiao-bing, LI Ling, WANG Li-xin,HE Yu-ping, LIANG Yi (Central Laboratory, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou 510405,China);Influence of Different Parts of Acori Tatarinowii on Neuropeptide Y Content in Pentylenetetrazol Kindling Rats[J];Progress in Modern Biomedicine;2010-14
7 YUAN Bao-qiang,GENG Hai-feng,LI Hui,FAN Qiu-ping,LI Rui,WANG Yun.Key Laboratory of Brain Diseases Bioimformation(Xuzhou Medical College)of Jiangsu Province,Department of Pediatrics,The Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China;Effects of extract of Ginkgo Bilob on cognitive function and expression of BDNF,NPY2R and synaptic reconstruction in juvenile rats with kindled seizure by pentylenetetrazol[J];Chinese Journal of Clinicians(Electronic Edition);2012-11
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YIN Yan-yan,GONG Hui-ling,LI Wei-zu(Dept of Pharmacology,Anhui Medical University,Hefei 230032);Effect of astragaloside on the disturbance of learning and memory of vascular dementia mice[J];Anhui Medical and Pharmaceutical Journal;2009-09
2 XIE Wei,BAO Yong,LI Chang-zheng,KANG Ping(Department of Traditional Chinese Medicine,Nan-fang Hospital, Southern Medical University,Guangdong Guangzhou 510515,China);The Effect of IL-6 Injected to Lateral Ventricle on Rat EEG and the Role of Saikosaponin a[J];Journal of Anhui Traditional Chinese Medical College;2007-03
3 HUANG Ying-chun~1,ZUO Ping-ping~2(1.Biochemical Engineering College of Beijing Union University,Beijing 100023,China;2.Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100005,China);The Inhibiting Effect of Buthus martensic Karch Extract(BmKE) on NMDA Receptor in Epileptic Mice[J];Journal of Beijing Union University(Natural Sciences);2006-04
4 LIU Hong-yan~1, XIE Xiang-lin~ 1* , ZOU Hong-bin~2, LIU Kai~1, LI Ye~1 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China; 2. Department of Nephrology,First Hospital, Jilin University,Changchun 130021,China);Effect of Acanthopanax senticosus injection on learning and memory of brain multi-infract rats[J];Journal of Jilin University(Medicine Edition);2006-05
5 Zhan Shu,Liu Wei,Shao Chunjie et al(Dept.of physiology,Central Laboratory of Physioloy,Dept.of organic chemistry);Influence of acanthopanax senticosides B(Sb)on the action potential of cultured myocardial cells in rats[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1995-01
6 MA Rong SHI Chang-ren LI Xin-min(The First Hospital Affiliated to Tianjin University of TCM,Tianjin 300193,China);Interference effect of Kangxianzengzhi capsule on hippocampal mossy fiber sprouting in epileptic rat kindled by pentylenetetrazol[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-10
7 YANG Ji-wen1 WANG Wei2 YUAN Shu-guang2 ZHANG Qiu-cai2 ZHANG Li-min2 LI Ning2(1The Third Hospital Affiliated to Shijiazhuang City,Shijiazhuang 050011,China;2The People's Hospital of Hebei Province,Shijiazhuang 050071,China);Effect of Astragalus mongholicus and Salvia miltiorrhiza injection on expression of nerve cells apoptosis in acute intracerebral hemorrhage rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-10
8 LI Long-xuan, ZHAO Bin, XU Zhi-en, TANG Rong-hua. Department of Neurology, The Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, China;Prepared Radix Rehmanniae protects hippocampcal neurons of rats with Alzheimer's-like disease from amyloid-β peptide1-40 induced apoptosis[J];Chinese Journal of Neuromedicine;2006-01
9 Le ZHONG, Xia WANG, Xiao-He YU, Yu-Jia YANG. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China;Long-lasting behavioral alterations in neonatal rats after hypoxic-ischemic brain damage[J];The Chinese Journal of Contemporary Pediatrics;2005-03
10 WANG Jing-jing,LI Zhen-guang,DENG Yuan-jiang,et al.Hunan College of TCM,Changsha,410007,China;Clinical Investigation on the Antiepilepsia Effect of YuXianLing(YXL)[J];Journal of Chinese Physician;2001-11
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LEI Li1,LIU Gang2,XU Zhi-hui2,GUO Yi2,QI Bin-wu3(1.Department of Biochemistry,Shangluo Vocational & Technical College,Shangluo,Shanxi 726000;2.Institute of Phytochemistry,Sichuan Normal University,Chengdu,Sichuan 610101;3.School of Basic Medical Science,Shanxi University of Chinese Medicine,Xi'an 712046);Effect of the oil-cake of Descurainia sophia on the ability of learning and memory of mice[J];Anhui Medical and Pharmaceutical Journal;2011-01
2 Guo Yingshu(the First Affiliated Hospital of Henan College of Traditional Chinese Medicine,Zhengzhou,Henan,450000);Professor Zheng Shaozhou's Experience in Treating Epilepsy[J];Henan Traditional Chinese Medicine;2012-05
3 JIN Miao,AN Hong-mei,WANG Xiu-wei,YUAN Can-xing Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Clinical observation of combined "Guben Dingxiang Mixture" and "Xiewu Capsule" in treating epilepsy[J];Shanghai Journal of Traditional Chinese Medicine;2011-05
4 TANG Yan,LI Xiang,LI Juan,LI Hua(Department of Occupational and Environmental Medicine,Luzhou University of Medical Science,Luzhou 646000,China);Effect of noise on learning memory ability and monoamine neurotransmitter in hippocampus of immature rats[J];Chinese Journal of Industrial Medicine;2010-03
5 LU Zhi-wei1,LI Mei-zhen2,LU Xin2,FANG Zhi-zhong2(1.Department of Pharmacy,Metabolic Diseases Hospital,Tianjin Medical University,Tianjin 300052,China;2.College of Pharmacy,Tianjin Medical University,Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics,Tianjin 300070,China);Determination of danshensu sodium in shenhuatongmai capsules by HPLC[J];Journal of Tianjin Medical University;2012-02
6 WANG Yue1,LIU Jin-min2(1.2010 Doctorate Candidate of Beijing University of Traditional Chinese Medicine,Beijing 100029;2.Dongfang Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100078);Thinking and Countermeasures of Chinese Medicine in the Treatment of Drug Resistant Epilepsy[J];World Journal of Integrated Traditional and Western Medicine;2013-01
7 Li Jiahui;Liu Qilu;Gao Zhongyang;School of Medicine,Xi'an Jiaotong University;;Effects of difference in nerve excitation on mice ability of learning and memory[J];Shaanxi Medical Journal;2013-09
8 SU Jing1,HE Hai-bo2,SHI Meng-qiong2,XIONG Xing-jun3,CHEN Liang-jin2,LU Xun-cong2 1 Department of Pharmacy,Suizhou Central People's Hospital,Suizhou 441300,Hubei,China;2 Medical Science College,China Three Gorges University,Yichang 443002,Hubei,China;3 Department of Pharmacy,Traditional Chinese Medicine Hospital,Changyang 443500,Hubei,China;Effects of hemp seed oil on learning and memory performances in senile mice induced by D-galactose[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2011-12
9 HE Huan1,HOU Li2,HUANG Huang1,WANG Jing-qian2,FAN Mei-mei2,HE Ming1 1 Department of Pharmacology & Molecular Therapeutics,Nanchang University School of Pharmaceutical Science;2 National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,Jiangxi,China;Experiment study of Guanxinshu capsule attenuates anoxia/reoxygenation injury in neonatal rat cardiomyocytes by partial formulation analysis[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2011-12
10 WEI Jia,LU Da-xiang,QI Ren-bin,WANG Hua-dong(Department of Pathophysiology,Institute of Brain Research,Key Laboratory of State Administration of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou 510632,China.);Effect of Kangshuaiyizhi formula Ⅰ on learning and memory behavior and expression of ChAT in hippocampus of mice[J];Chinese Journal of Pathophysiology;2010-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Yan hui *, WANG Li (Dept of Pediatrics, 1st Teaching Hospital of Beijing University, Bejing 100034, China) now working at Dept of Pediatrics, Union Hospital of Fujian Medical University, FuZhou 350001, China;Effect of phenobarbital on spatial learning and hippocampal nNOS expression in epileptic rats[J];Basic Medical Sciences and Clinics;2001-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved