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《Journal of Southeast University(Medical Science Edition)》 2007-04
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Influence of radix salviae miltiorrhizae on the learning and memory and level of AChE and ChAT in hippocampus of status epilepticus juvenil rats

SUO Guo-ling1,TANG Hong-li1,2,WANG Xiu-li1(1.School of Clinical Medicine,Southeast University,Nanjing 210009,China;2.Department of Pediatrics,Institute of Clinical Medical Research,Nanjing 210009,China)  
Objective To establish status epilepticus(SE) animal model and investigate the influence of radix salviae miltiorrhizae(RSM) on the learning,memory and level of AChE and ChAT in hippocampus.Methods A juvenile rat model of SE was established by injection of pentylenetetrazole intraperitoneally.The rats were treated with radix salviae miltiorrhizae(RSM),phenobarbital(PB),respectively.The learning and memory were tested by Morris water maze after 7 days,level of AChE and ChAT in hippocampus was examined by homogenate colorimetric method.Results In PTZ group,the time for the rats to find the hiding flat were prolonged(P0.05),the time of target quadrant retention reduced(P0.01),the percentage of the effective searching strategy reduced(P0.01),level of AChE and ChAT in hippocampus of status epilepticus decreased(P0.01),both RSM and PB group improved learning and memory disorder after SE respectively.RSM group increased the level of AChE and ChAT after SE,PB group only increased the level of AChE.Conclusion SE can damage learning and memory of juvenil rats,AChE and ChAT may participate the process of the pathological and physiological change.RSM intervention may improve learning and memory of juvenil rats through repair choline system of hippocampus.
【CateGory Index】: R285.5
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