Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《南京医学院学报》 1991-03
Add to Favorite Get Latest Update

Effects of Anisodamine on Isolated Guinea Pig Atrium and Rabbit Aorta

Liu Guangyu  
In spontaneously beating right atria of guinea pig, anisodamine (654-2) could antagonize Ca~(2+)-induced positive chronotropic response. Similar to verapamil (Ver), 654-2 shifte isoprenaline (Iso) dose-response (beat rate) curve non-parallelly to the right with decrease of its maximum effect, showing non-competitive antagonism. 654-2 and Ver produced frequency-dependent depression of contractile force of guinea pig left atria but Ver could inverse the frequency-contractile curve from positive staircase into negative one. Both 654-2 and Ver had inhibitory effects on post-rest potentiation. In isolated rabbit aorta, 654-2 had antagonist effect against two contractile compoments induced by norepinephrine. The data showed that 654-2 shifted Ca~(2+) dose-response (contraction) curve non-parallelly to the right with decrease its maximum effect in high K~+ (40mM) solution, showing non-competitive antagonism. This study indicates that 654-2 exerted negative inotropic and chronotropic effects in isolated vessels and atria because 654-2 might inhibit two calcium channels (PDC and ROC) and release of intracellular calcium. These results suggest that 654-2 possesses non-specific calcium-antagonism.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Liu Guangyu;PROTECTIVE EFFECTS OF ANISODAMINE 0N LEFT VENTRICULAR DIASTOLIC FUNCTION DURING MYOCARDIAL ISCHEMIA IN RATS[J];;1989-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Lai;Effects of Anisodamine on the Decrease of Na~+-K~+-ATPase Activity Iinduced by Oxygen Free Radicals[J];Journal of Dalian University;1994-03
2 Li Junbo; Liu Li; Ren Xin; Leng Ping (Medical College of Dalian University, China);Effects of Anisodandne on Cytoplasndc Free Calcium ([Ca~(2+)]_i) in Isolated Ventricular Myocytes[J];JOURNAL OF DALIAN UNIVERSITY;1999-02
3 Xu Ruxiang ,Yi Shengyu , Wang Boyun Department of Neurosury, Zhujing Hospital Department of Neurosurgery, Xijin Hospital Fourth Military Medical University, Xian (710032);Effect of anisodamine on changes of blood-brain barrier permeability following brain injury in rabbits[J];Journal of First Military Medical University;1992-04
4 Xu Ruxiang. Yi Shengyu, Wang Boyun. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi-an;THE CHANGES OF BRAIN WATER, Na~+, K~+ CONTENTS AND BLOOD-BRAIN BAR-RIER IN ACUTE EXPERIMENTAL BRAIN INJURY[J];Medical Journal of Chinese People's Liberation Army;1991-02
5 Xu Ruxiang. Department of Neurosurgery, Zhujiang Hospital, First Military Medical University, GuangzhouYi Shengyu. Deparlment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi' an;EFFECT OF ANISODAMINE ON CHANGES IN CALCIUM AND CALMODULIN CONTENTS IN THE BRAIN TISSUE AND THE BLOOD FOLLOWING BRAIN INJURY[J];Medical Journal of Chinese People's Liberation Army;1992-04
6 Zhang Qingzhu (Department of pharmacology,Jining Medical College);STUDY ON MECHANISM OF BLOOD VESSEL DILATION ALKALOIDS[J];Journal of Jining Medical College;1991-04
7 Liu Min Fang Gaohong (Department of pharmacology, Jiangxi Medical College);Study of Antagonistic Effect of Total Alkaloids of Corydalis Amabilis Migo on Calcium[J];Acta Academiae Medicinae Jiangxi;1989-03
8 Hou Jianping,Liu Yaochun ,Lu Hongying,et al Department of Phsiologhy, Weifang Medical College , Weifang, 26 1 04 2;EFFECTS OF ANISODAMINE ON CORONARY BLOOD FLOW ANDVENTRICULAR FIBRILLATON THRESHOLD IN ISOLATED RABBIT HEART[J];JOURNAL OF WEIFANG MEDICAL COLLEGE;1997-01
9 Liu Guangyu;PROTECTIVE EFFECTS OF ANISODAMINE 0N LEFT VENTRICULAR DIASTOLIC FUNCTION DURING MYOCARDIAL ISCHEMIA IN RATS[J];;1989-02
10 Physiololgy Teaching Reserch Room of Xinjiang Medical college Ainur Xuekelaiti 830000;Effects of Essradiol and Progesterone on Contraction of chronic Hypoxic Vascular strips in Vitro[J];Journal of Practical Medical Techniques;2000-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Guo Dianling Luo Han Chen Guangwen Luo Zhengyao Department of Pathophysiology, Hunan Medical University;EFFECT OF ANISODAMINE ON ARRHYTHMIAS IN CALCIUM PARADOX ISOLATED RAT HEARTS[J];;1989-02
2 Xu Zichao,Li Xiaohua , Yao Xiujuan , et al. Fourth Military Medical University. Xi' an , 710032;FFECT OF ANISODAMINE ON THE CONTENT OF PRINCIPAL,FATTY ACIDS INTHE MEMBRANE LIPIDS OF ISCHEMIA REPERFUSED MYOCARDIAL INJURIES[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1994-05
3 Chen Qiongfang Zhou Sulian Hu Youchang Cao Zequn (Department of Pathophysiology, Jiangxi Medical College, Nanchang);Proteetive Effect of Anisodamine on the Injury of Renal Ischemia and Reperfusion[J];Acta Academiae Medicinae Jiangxi;1991-02
4 Yang,Kegong; He,Ping; Chen,Song-sen; Jia,Pei-chen; Liang, Zhi-quan(Liang,Chih-chuang)(Institute of Basic Med Sci, Chinese Academy of Med Sci, Beijing 100005);Two Drugs Stimulate γ-Globin Gene Expression in K562 Cells[J];;1994-03
5 Liu Wenjie Department of Electron Microscopy, Xinjiang Medical College;Lanthanum Nitrate Tracer and Electron Microscopic Study on Rabbit Myocardial Reperfusion Damage and Protective Effect of Anisodamine[J];Journal of Xinjiang Medical University;1991-04
6 ZHANG Ying-Ge, KE JunDepartment of Pharmacology, Henan Medical University, Zhengzhou 450052;Influence of hebane drugs on cerebral and myocardial blood flow and cardie index in rats[J];Chinese Journal of Pharmacology and Toxicology;1992-02
7 ZHANG Ming-Zhi, CHEN Jing-Ming, ZHONG Yan-Yan, ZHANG Guang-Yi Department of Cell Regulation, Xuzhou Medical College, Xuzhou 221002;Effects of atropine, scopolamine and anisodamine on the proliferation of rabbit aortic smooth muscle cell[J];Chinese Journal of Pharmacology and Toxicology;1992-02
8 CAO Zhao-Feng,WANG Qiu-Ju,LUO Ling,FU Ding-Yi(Laboratory of Immunopathology and Cytotoxicology,Department of Pharmacology,North China Coal Medical College,Tangshan 063000);Scavenging effect of anisodamine on superoxide anion radical and its protection on sulfhydryl group in erythrocyte membranes of rats in vitro[J];Chinese Journal of Pharmacology and Toxicology;1993-03
9 Xie Jingxi, Zhou Jin, Jia Xiaoxian and Liu Chunxue. (Institute of Materia Medica, Chinese Academy of Medical Sciences Beijing) XU Huiqin, Fang Anshi, Wang Jinzhi and Xia Boyang (Beijing Pharmaceutical Factory);STUDIES ON THE SYNTHESIS OF ANISODAMINE[J];Acta Pharmaceutica Sinica;1980-07
10 Wang Ying-Wei,Hao Xing-Zhi,et al Department of Immunopathology,Xuzhou Medical College,Xuzhou;Effects of Verapamil and Anisodamine on pathologic changes of passive Heymann nephritis in rats[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1994-03
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 GUO Zhen hui, HONG Xin, MAO Bao ling, QIAN Gui sheng, CHEN Zheng tang (Research Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037,China);Effects of ansodamine on the activation of nuclear factor kappa B in vitro[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-06
2 ZENG Jun-fa,XIAO Hong,GUI Pei-gen(Department of Intensive Care Unit,the Second Affiliated Hosptial,University of South China, Hengyang,Hunan 421001,China);The Effect of PHCD on the Expression of NF-κB in Acute Lung Injury Rabbits[J];Journal of Medical Science in Central South China;2012-01
3 JIANG Zidong LIU Wen ZHAO Cuixia ZHANG Lianshan (Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing,100730,China);Adjuvant treatment of anisodamine to acute serous otitis media[J];Journal of Clinical Otorhinolaryngology;2004-07
4 ;长春西汀与丁咯地尔治疗梅尼埃氏病临床疗效观察[J];Nei Mongol Journal of Traditional Chinese Medicine;2013-05
5 WU Hao,CHAO Fu,YANG Hong-sheng,et al.(Department of Thoracic Surgery, the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China);Experimental study on protective effect of anisodamine on lung ischemia-reperfusion injury in rabbits[J];Medicine and Pharmacy of Yunnan;2005-01
6 Zhang Changhua, Xu Donghui, Mei Xueting, Xu Shibo (School of Pharmacy, Zhongshan University, Guangzhou 510275);Advances in Study on the Nature Products of Anti-myocardial Ischemia[J];Journal of Chinese Medicinal Materials;2003-04
7 Ding Yungang, Liu Shanda( Chaozhou Hospital, GuangDong,Chaozhou 521011 ,P. R. China);Clinical Study of Therapeutic Effect of Anisodamine Ointment in Local Treatment on Diabetic Foot[J];China Pharmacist;2006-07
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved