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《Acta Academiae Medicinae Nanjing》 2001-03
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Effect of Propofol on Heart Conduction System

JIANG Xiu hong, FU Cheng zhang, CHEN Chun 1 (Department of Anesthesiology, 1 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Nanjing 210029,China)  
Objective:To investigate the effects of propofol on heart conduction system. Methods:Twenty patients were randomly divided into two groups. In group A ( n=10) propofol(1.5 mg·kg -1 ) was first infused and then 3 mg·kg -1 ·h -1 continuous infusion; and in group B ( n= 10) propofol (2 mg·kg -1 ) was first infused, and then 4 mg·kg -1 ·h -1 continuous infusion. Before and after infusion of propofol, HR, SACT, SNRT MAX , CSNRT, SNRTI, WB, P R interval and QRS were monitored. Results:SACT( P 0.01) was lengthened in two groups, and 2 mg·kg -1 of propofol decreased the WB. The others had no significant change. Conclusion:Propofol may have an obvious depression effect on the heart conduction system in a dose dependent manner.
【Fund】: 江苏省自然科学基金资助项目 ( 798DA970 3 )
【CateGory Index】: R971.2
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