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《Acta Academiae Medicinae Nanjing》 2001-04
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Clinical Application of 153 Times Membrane Plasmapheresis

YU Xiang-bao, WANG Xiao-yun, HUANG Gui-ying, ZHAO Wei-hong, HU Jian-ming, SHEN Xia (Department of Nephrology, the First Affiliated Hospital, Nanjing Medical University, Jiangsu Nanjing, 210029, China )  
Objective:To summarize clinical data of membrane plasmapheresis(PP) and compare removal effect of IgG, IgA, IgM, C 3, C 4,CH 50 of single filtration PP as double filtration PP. Methods:153 treatments of PP (single 77, double 76) were performed on 62 patients who suffered from progressive systemic sclerosis(in 18), chronic hemodialysis(in 13), SLE(in 5), myasthenia gravis (in 5), hyperviscosity syndrome(in 4), acute Guillain-Barre syndrome(in 9). Serum and filtrate levels of IgG, IgA, IgM, C 3, C 4, CH 50 and protein eletrophoresis were measured before and after a single course PP. Results:Serum levels of IgG, IgA, IgM, C 3, C 4,Ch 50 after double filtration PP were signifficantly reduced as compared with before double filtration PP (P0.005). The same time, serum levels of C 3 after single filtration PP was not signifficantly reduced (P0.05). Incidence of side effects was 10.45% (single filtration PP: 18.18%, double filtration PP:2.63%). Conclusion: PP was more safety and effective therapeutics that removing of immunoglobutin. The removation of IgG with double filtration PP was more effective.
【CateGory Index】: R459.5
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