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《Acta Academiae Medicinae Nanjing》 2004-01
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NF-κB Expression in LPS Induced Acute Lung Injury in Mice

ZHU Zi-lu,XIONG Jun,XU Hua,LU Shan-hua,SUN Ai-min(Department of Biochemisty and Molecular Biology,NJMU,Nanjing 210029,China)  
Objective:To investigate the function of nuclear factor-êB(N F- êB) in acute lung injury(ALI),the dynamic change of NF-êB in lung of ALI was detected. Methods:Twenty five male mice were divided into five groups at random . There were normal control group and four acute lung injury groups at different time point.The lipopolysaccharide(LPS)was admistrated by intraperitoneal inje ction. Expression of NF-êB was detected by the methods of Western-blot and im munohistochemistry. Results:Expression of NF-êB began to increase after injec ting LPS in the first hour,arrived the peak in the third hour and then decreased . Conclusion:NF-êB may be a key medium in ALI.
【CateGory Index】: R563.8
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