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《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2006-04
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Effects of curcumin on spatial learning and memory of vascular dementia rats

ZHANG Shu-gang, HU Mei, ZHOU Qi-gang, WANG Wei, ZHU Dong-ya(Department of Pharmacology, School of pharmacy, NJMU, Nanjing 210029, China)  
Objective: To investigate the effects of curcumin on spatial learning and memory of vascular dementia rats induced by a permanent bilateral ligation of common carotid arteries (2VO). Methods: SD rats were randomly divided into sham-operated, vehicle-treated and curcumin-treated group. The levels of O2.- and .OH were detected at 2 weeks after the surgery. The morris water maze test was performed to detect the effects of curcumin on spatial learning and memory of vascular dementia rats at 4 weeks and 8 weeks after the surgery. HE and immunocytochemistry were performed to investigate the cell number of CA1 subfeild of hippocampus. Results: Curcumin can significantly decrease the levels of O2.- and .OH. The spatial learning and memory of vascular dementia rats were impaired and that of the curcumin-treated group was ameliorated. HE and immunocytochemistry proved the difference of the cell number of CA1 subfield of hippocampus. Conclusion: The results demonstrate that curcumin can alleviate the impairment resulted from vascular dementia by reducing the level of free radical and the cell death of CA1 subfield of hippocampus.
【Fund】: 江苏省高校自然科学基金资助项目(03KJB310083)
【CateGory Index】: R285.5
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