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《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2006-12
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The experimental research of setting up the subsiding model of avascular necrosis of femoral head

GU Xiao-feng, LI Feng-feng1, FAN Wei-min2, LIU Jun1, XU Kai3(Department of Orthopaedics, Wuxi City First People Hospital Afliliated to NJMU, Wuxi 214002; 1Department of Orthopaedics, the Second Affiliated Hospital of NJMU, Nanjing 210011; 2Department of Orthopaedics, the First Affiliated Hospital of NJMU, Nanjing 210029; 3Department of Orthopaedics, Tongji Hospital of Huazhong University of Science and Technology, Wuhan 430003, China)  
Objective:To research the method of establishing subsiding model of avascular necrosis of femoral head. Methods: Femoral heads were frozen by liquid nitrogen, and the blood vessel and parenchyma of fundus were destroyed. X-ray and histology examination were made periodically after operation to evaluate osteo necrosis and the subsequent repair. Results:Necrosis of the femoral head was confirmed by histology in the thirty week?the seventh week and the eleventh week after operation, but repairing is not obvious. Radiographic evidence and gross observation showed Necrosis of the femoral head, but obvious subsiding appeared in the eleventh week. Conclusion:The typical animal subsiding model of avascular necrosis of the femoral head can be established with blood vessel destroy and liquid nitrogen freezing.
【CateGory Index】: R-332
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