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《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2009-07
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Molecular epidemiology of the human immunodeficiency virus-1 isolated from patients confirmed lately in Jiangsu province

YANG Hai-tao,XU Xiao-qin,QIU Tao,HUAN Xi-ping,HU Hai-yang,GUO Hong-xiong (Jiangsu Center for Disease Prevention and Control,Nanjing 210009,China)  
Objective:To analyze the subtypes distribution of Human Immunodeficiency Virus-1 (HIV-1)in Jiangsu province,and the relationship between subtypes and transmission route. Methods:83 blood samples with EDTA-K3 were collected from population with HIV-1 confirmed lately using western blot test. Viral RNA was extracted from plasma and used by a RT-nest PCR to amplify the env and gag gene of HIV-1. The PCR amplimers were partially sequenced on ABI 3730. After sequences alignmented by ClustalX, phylogenetic analysis was performed using MEGA 3.1 software. Results:7 subtypes including CRF01_AE,CRF07_BC,CRF08_BC, B,C,CRF02_AG,A1 were found circulating in Jiangsu. 3 predominated clades were CRF 01_AE,CRF07_BC,and B,which accounted for 31.6%,25%,and 19.7%,respectively. 5 subtypes consisting of CRF07_BC,B,CRF01_AE,C,CRF08_BC,circulated in population via heterosexual contact,and CRF 07_BC accounted for 32.6%,B was 23.3%,and CRF 01_AE was 20.9%. CRF 01_AE, CRF 07_BC,B,CRF 08_BC circulated among men who sex with men having HIV-1,and CRF 01_AE was dominative. The circulated HIV-1 subtypes among IDUs included CRF 07_BC、B、CRF 01_AE、A1、CRF 02_AG,CRF 01_AE was the dominated,which accounted for 58.4% . Conclusion:There were more kinds of subtypes circulating in Jiangsu than other province. Of 7 subtypes,5 except CRF02_AG and A1 were found in population with HIV-1 via heterosexual contact. The increasing complex characteristic of HIV-1 sequences may be associated with acquiring HIV via sexual intercourse.
【Fund】: 江苏省科技厅社会发展计划资助项目(BS2006078)
【CateGory Index】: R181.36
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