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《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2010-01
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Toxicokinetic study on intravenous infused LHPLC(hydroxycamptothecin liposome)by beagle dog model

ZHAO Hong-yan,GAO Rong,CHEN Wen-zhong1,ZHUANG Yi1,CHENG Guang1,XIAO Hang(School of Public Health,NJMU,Nanjing 210029;1Nanjing SiKe Medicial Co.,Ltd,Nanjing 210061,China)  
Objective:To study the toxicokinetics of LHCPT in Beagle dogs by intravenous infusion,and discuss the accumulative effects of LHCPT in blood.Methods:HPLC with fluorescence detection was used to analyze drug concentration in whole blood.Results:Cmax and AUC were increased in a dose-dependent manner both after 1st day and 30th day;and there was no statistical significance in t1/2 of different doses(P 0.05).Compared with single administration with repetition,there were no obvious changes of AUC,Cmax and t1 /2 of the same dose(P 0.05).Conclusion:LHCPT has no significantly accumulative effects after successive intravenous administration.
【Fund】: 国家自然科学基金资助(30771831)
【CateGory Index】: R96
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