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Flow Cytometry Analysis of Cellular DNA Content of the Parotid Pleomorphic Adenoma

Zhang Yuan Yang Jianrong * Zhou Zhenying ** Department of Head and Neck Surgery, ** Department of Immunology, Jiangsu Tumour Hosptial, Nanjing\ 210009 *Department of Oralmaxilofacial Surgery, Nanjing Medical University, Nanjing\ 210029  
The nuclear DNA content in 42 cases of primary parotid pleomorphic adenoma (PPA) and 15 cases of recurrent PPA were analysed with flowcytometer (FCM) to study the correlation of the DNA index (DI), S% and cellular proliferous index (PI) with the biologic behaivor of the tumor. The results indicated that in a portion of pleomorphic adenoma, the nuclear DNA content had altered and possessed malignant potential before any evidence of malignancy could be found under lightmicroscope. The increase of S% and PI, which followed the course of tumor development, has a close relation with the capsular invasion and the recurrence. There was a significant difference on the DI, S%, PI as well as the incidence of heteroploid between the recurrent and the incipient tumor. A great portion of recurrent tumors, which still diagnosed as benign pathologically, was acually heteroploid.
【CateGory Index】: R739.87
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Chinese Journal Full-text Database 3 Hits
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