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《Journal of Nanjing University of Traditional Chinese Medicine》 2003-03
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Effect of Electrical Acupuncture on Long-term Potentiation of Excitatory Postsynaptic Potential of Rat Hippocampus

MA Cheng, YAN Li-ping, SHEN Hong-mei (Key Acupuncture Laboratory of Jiangsu , Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu , 210029,China)  
OBJECTIVE To observe the effect of electrical acupuncture on long-term potentiation (LTP) of excitatory postsynaptic potential (EPSP) of normal rats and rats with hypomnesia induced by scopolamine. METHOD EPSPS of the dentate gyrus granular cell layer of the rat hippocampus was induced and strong stimulation was given to the cerebral cortex anterior perforated substance to cause LTP reaction. Animal models with hypomnesia induced by scopolamine were made so as to observe the effect of electrical acupuncture at Dazhui and Shenshu on LTP. RESULT The inducing effect on LTP in the electrical acupuncture group was stronger and lasted longer than that in the non-electrical acupuncture group, and part of the parameters and durations were statistically significant ( P 0.05). Scopolamine i.p could inhibit LTP ( P 0.01) and electrical acupuncture could markedly antagonize this inhibiting effect ( P 0.01; P 0.05). CONCLUSION Electrical acupuncture facilitates LTP and has antagonizing effect on hypomnesia induced by scopolamine.
【Fund】: 江苏省中医管理局基金项目 (970 10 1)
【CateGory Index】: R245.97
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