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Study on the Protective Effects of Schizandrin on 6-OHDA-induced Apoptosis of Cultured PC12 Cells

LI Hai-tao 1, HU Gang 2 ( 1Nanjing university of Chinese Medicine, Nanjing,Jiangsu, 210029, China. 2Institute of Pharmacology and neurobiology, Nanjing Medical University, Nanjing,Jiangsu,210029, China)  
OBJECTIVE To study the protective effects and mechanisms of Schizandrin(SCH) on 6-OHDA-induced PC12 cells apoptosis. METHODS The viability of PC12 cells was investigated by MTT method; The glutamate uptake into PC12 cells was measured by using radioimmunoassay method; The extracellular glutamate levels of PC12 cells was detected with HPLC. RESULTS Treatment with 6-OHDA produced inhibitory effect on viability and glutamate uptake into cells. Incubation with SCH caused increase in the viability and glutamate uptake into PC12 cells, which completely reversed 6-OHDA-induced uptake inhibition. CONCLUSION SCH may modulate glutamate transporters and reduce extracellular glutamate levels, through which it protects PC12 cells against 6-OHDA -induced injury and may be useful in the treatment of PD.
【Fund】: 江苏省博士后基金资助
【CateGory Index】: R285.5
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