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《Acta Scientiarun Naturaltium Universitatis Nankaiensis》 2004-02
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STUDIES ON ATIOXIDANT EFFECTS AND MECHANISM OF CHINESE HERB ROSA RUGOSA THUNB

NIU Shumin, ZHU Songhua, LI Wei, WANG Dong, WANG Chunhua, LIU Fang( College of Life Sciences, Nankai University, Tianjin 300071, China; Tianjin Municipal Center for Sanitation and Disease Prevention, Tianjin 300011, China )  
To examine the antioxidant effects of Chinese herb Rosa rugosa Thumb(F21)in vivo of mice, and explore the mechanism of antioxidation, Erythrocyte hemolysis, Lipid peroxidation in liver homogenates, determination of superoxide dismutase (SOD) activity and Reverse transcription-polymerase chain reaction (RT-PCR) were used.After treating young, middle-aged are old mice, F21 showed different antioxidant activities. In mice over 8 months, F21 displayed prominent antioxidant activity and strongly increased the mRNA expression of Cuzn-SOD gene. F21 displayed strong antioxidant activities. Especially in mice of 8 months, F21 not only had prominent antioxidant effects in the level of cells and tissues, but also improved the mRNA expression in level of molecule. In summary, F21 had components with effective antioxidant activity and was a good naturally antioxidant, so it will be of further study's value.
【Fund】: 天津市自然科学基金重点资助项目(023803211) 国家自然科学基金资助项目(30270039)
【CateGory Index】: R285
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