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《Acta Scientiarum Naturalium Universitatis Nankaiensis》 2018-06
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The Vegetarian and Physical Activity Protects Rhesus Monkeys against the Development of Atherosclerosis in an Aging Independent Manner

Liu Lipei;Ma Chuanrui;Zhang Xiaomeng;Yang Xiaoxiao;Han Jihong;Duan Yajun;Chen Yuanli;Li Xiaoju;College of Biomedical Engineering, Hefei University of Technology;Key Laboratory of Bioactive Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University;State Key Laboratory of Medicinal Chemical Biology, School of Medicine, Nankai University;  
Monkeys are an ideal animal model for investigation of the pathophysiology of human diseases. We attempted to unveil if monkeys can develop atherosclerosis by aging. We collected blood, aortas and liver samples from the rhesus monkeys at-9, 17, 25 ages. Associated with aging, we did not find lesions developed in monkey aortas. Correspondingly, a high integrity and unchanged elastic fiber content in arterial wall were observed. No infiltration/accumulation of monocyte/macrophages was found either. In macrophages derived from blood monocytes collected from monkeys at different ages, we found ABCG1 expression was increased with ages or in response to tamoxifen treatment. In the liver, ABCG1 expression is relatively stable while SR-BI expression was decreased. In contrast, expression of PCSK9 and CD36 was increased. However, the lipid profile assay shows that pro-atherogenic LDL-cholesterol levels were constant. Taken together, our study demonstrates that age is not a natural risk factor for atherosclerosis in monkeys which might be due to the healthy lifestyle, such as no cholesterol intake and high physical activities, in the animals.
【Fund】: 国家自然科学青年基金(31770863 81773727 81722046);; 天津市自然科学基金(17JCYBJC25000 16JCZD JC347007)
【CateGory Index】: R543.5
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