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《Acto andrologica Sinica》 2003-02
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Changes of 5 Alpha-reductase Type Ⅱ Activity in Sexual Gland of Diabetic Male Rats

Hong Jun WANG 1 , Jia Ying ZHANG 2 , Su Huan LIU 1 , Hui ZHAO 1 , Zhong Shan WANG 1 (1 Department of Cell Biology, 2 the Second General Laboratory, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China)  
Objectives: To study the changes of sexual gland 5α reductase type Ⅱ activity in pubertal and adult rats with diabetes.Methods: We selected 40 and 90 days old male Wistar rats as pubertal and adult animal model respectively, 30 rats in each group. The rats were randomly divided into three groups: control group (C), diabetic group (D) and diabetes with insulin replacement group (ID). The activity of 5 α reductase type Ⅱ was measured with thin layer chromatography in the epididymis, prostate and testis. Results: ① In all sexual glands of pubertal rats, the activity of 5α reductase type Ⅱ in D group is significantly lower than that in C and ID groups. ② In all sexual glands of adult rats, there is no difference in the activity of 5α reductase type Ⅱ among these groups. Conclusions: The activity of 5α reductase type Ⅱ is likely to be influenced by metabolic environment, hormonal levels and local specific factors in pubertal rats, but it is relatively stable in adult rats.
【Key Words】: Diabetes 5α reductase type Ⅱ Sexual gland Rat Male
【Fund】: 国家自然科学基金资助 ( 3 9870 3 13 )
【CateGory Index】: R587.1
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