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《Acto andrologica Sinica》 2003-05
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Infection of Chlamydia Trachomatis and Apoptosis of Spermatogenic Cells

Chang Chun WAN 1 , Hong WANG 1 , Bao Jin HAO 1 , Xue Jun SHANG 2 , Yu Feng HUANG 2 (1.The People' s Hospital of Jinhu, Jinhu, Jiangsu 211600, China; 2.Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002,China)  
Objective: To evaluate the relationship between infection of Chlamydia Trachomatis(Ct) and apoptosis of spermatogenic cells. Methods: Apoptotic spermatogenic cells were examined by Wright Giemsa staining and the terminal deoxynucleotdyl transferase mediated deoxyuridine triphosphate(dUTP) biotin nick end labeling(TUNEL) technique. Results: Apoptosis rate of Ct infective group was significantly higher than that of normal group( P 0.01 ). Conclusions: Ct infection may cause the apoptosis of spermatogenic cells, which affords an objective evidence for illustrating the mechanism of Ct infection induced male infertility.
【Fund】: 江苏淮安市社会发展基金资助 (SJ2 0 0 10 4 4)
【CateGory Index】: R363
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