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《Acto andrologica Sinica》 2004-02
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Effects of ZJG on the Quality of Sperm in Male Rat Epididymis

Du Weiliang, Chang Degui, Zhang Taijun, Wang Jiuyuan, Zhang Shuwu, Tang Bo Department of Traditional Chinese Medicine, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China(Du WL,Tang B); Department of Andrology, the Affiliated Hospital of Chengdu Traditional Chinese Medical University, Chengdu, Sichuan 610075, China(Chang DG, Zhang TJ, Wang JY, Zhang SW)  
Objective: To observe the effects of Chinese herbal composition Zengjing Granule (ZJG) on the quality of sperm in the epididymis of infertile rats, and to study its therapeutic mechanisms of improving sperm quality. Methods: A total of 40 GTW infertile rats were divided into 4 groups of 10 rats each, including an infertility group[GTW 2 mg/(ml·100 g)], a high-dosage group [ ZJG 0.67 g/(ml·100 g)+GTW 2 mg/(ml·100 g)], a medium-dosage group [ZJG 0.33 g/(ml·100 g)+GTW 2 mg/(ml·100 g)],a low-dosage group [ ZJG 0.17 g/(ml·100 g)+GTW 2 mg/(ml·100 g)], and a normal control group(1%CMC). This study consisted of a 3-week modeling period and a 3-week ZJG period. The changes of sperm quality, the thickness of the epididymal gland canal wall and sexual organ coefficient were detected after 3-week ZJG period. Results: Of the 3 ZJG groups, the sperm density was ( 59.6± 3.72), ( 63.3± 5.70) and ( 69.7± 6.91) ×10 6/ml, the sperm motility rates were ( 65.4± 6.33)%, ( 69.3± 10.96)% and ( 72.6± 9.61)%, the sperm deformity rates were ( 52.3± 7.47)%, ( 46.2± 7.73)% and ( 33.2± 7.97)% repectively. The ZJG groups showed significant difference from the infertility group (P 0.05), whose sperm density, motility and deformity were ( 13.1± 6.81)×10 6/ml, ( 7.6± 5.87)%, and ( 77.2± 8.75)% respectively. But there was no significant difference between ZJG groups and the normal control group(P 0.05), whose sperm density, motility and deformity were ( 75.6± 10.82)×10 6/ml, ( 83.00± 8.02)%, and ( 8.80± 3.49)% respectively. The thickness of the epididymal gland canal wall was ( 37.07± 3.38), ( 37.16± 6.69) and ( 43.42± 10.23) nm in the three ZJG groups respectively, different from the infertility group[ ( 28.65± 6.96) nm] (P 0.05) significantly, but not from the normal control group [( 45.79± 11.13) nm] (P 0.05). The ZJG groups showed an increase in the organ coefficient of the epididymal gland canal wall. And these was obvious statistical difference compared with the infertility group (P 0.05), but no statistical significance compared with the normal control group (P 0.05). Conclusions: ZJG can obviously improve the sperm quality of infertile rats. Its therapeutic mechanisms can be summed up as follows: restoring the thickness of epididymal gland wall, increasing the organ coefficient of testes and epididymis, and hence improving the spermatozoa maturing function of epididymis of infertile rats.
【CateGory Index】: R285.5
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