Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Nationlal Journal of Andrology》 2005-09
Add to Favorite Get Latest Update

The Changes of IGF-Ⅰ in Testis and Epididymis on a Rat Model with Oligoazoospermia/azoospermia Induced by Cyclophosphamide

SHEN Guo-qiu~(1),LU Gong-cheng~(2),PAN Tie-jun~(1),XIAO Ya-jun~(2)1.Department of Urology,Wuhan General Hospital of Guanzhou Command,PLA,Wuhan,Hubei 430070,China;2.Department of Urology,Union Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430000,China  
Objective: To evaluate the effect of the levels of IGF-Ⅰin the epididymis and the expression of IGF-Ⅰ in the testis of adult male rat after the administration of cyclophosphamide.Methods: Ninety-six male adult rats(8 weeks age)were divided into 6 groups.The doses given to the rats of the groups 1 to 5 were 10,20,40,80 and 100 mg/(kg·d),respectively.The remaining group was served as control.All those rats were sacrificed and IGF-I were quantitatively determined by ELISA techniques 2 and 4 weeks after the administration of the drug(by gastric fudge).Immunohistochemical SP technique was used to examine expression of IGF-I in rat testis. Results: The levels of cell factors(IGF-I)in the epididymis of the rats were gradually reduced with the increasing time and dose after administration of the drug.In the mean time the expression of IGF-I in the tissues of the testis of those rats were also gradually reduced.Conclusion: In the time of oligozoospermia/azoospermia induced by the administration of cyclophosphamide,the expression levels of IGF-I in the genetic system were significantly reduced.The possible mechanism of these changes could be attributed to the lower spermatogeneous function of the testis caused by the administration of cyclophosphamide.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 9 Hits
1 GU Yi-peng;LUO Ping;School of Food Science & Technology,Guangdong Ocean University;;Interventional Effects of Sepia Polysaccharide against Cyclophosphamide-induced Oxidative Stress Injury to Testis of Mice[J];安徽农业科学;2014-19
2 XU Xin;GUO Xiao-Qi;CUI Hai-Bo;YANG Yang;LIU Qing-Xin;CUI Wei-Zheng;College of Forestry,Shandong Agricultural University;;Effects of Chemotherapeutic Drug Cyclophosphamide on Blood Cell Density and Sperm Cell Development of Silkworm,Bombyx mori[J];蚕业科学;2013-05
3 Yang Qunfang(Children's Hospital of Chongqing Medical University,Chongqing 400014,China);The Study Progress of Cyclophosphamide Toxicity on the Male Reproductive System[J];儿科药学杂志;2013-03
4 LUO Wenhai.Department of Hygienics,Yantai School Area of Binzhou Medical College,Shandong Province 264003;Effects of Cyclophosphamide on Reproductive Function of Rats[J];医学理论与实践;2011-06
5 LUO Shao-bo1,HU Hai-xiang1,JIA Jin-ming2(1 Center of Andrology,General Hospital of Air Force,Beijing 100142;2 Department of Andrology,Guang'anmen Hospital,China Academy of Chinese Medical Scienes);Intervention effect of Yijing Formula on sperm apoptosis in mouse model of oligoasthenospermia induced by CTX[J];北京中医药大学学报;2011-02
6 LUO Shao-bo1,JIA Jin-ming2,HU Hai-xiang1,MA Wei-guo2,JIAO Yong-zheng2,DONG Jia-chen21.Department of Andrology,General Hospital of Air Force,PLA,Beijing 100142,China;2.Department of Andrology,Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100053,China;Yijingfang increases the expression of CatSper1 in mice[J];中华男科学杂志;2010-11
7 ZHANG Wei-xing,LI Rui,WANG Rui,WANG Hua-li,HE Wei.Department of Urology,the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052,China;~(60)Co-γirradiation to establish the azoospermia male mice model[J];中华实验外科杂志;2010-07
8 LUO Shao-bo,HU Hai-xiang,JIA Jin-ming.Department of Andrology,General Hospital of Air Force,Beijing 100142,China;The effects of cyclophosphamide peritoneal injection to mice spermatozoa[J];空军总医院学报;2010-01
9 Shen Guoqiu~(1*),Lu Gongcheng~2,Pan Tiejun~1,Xiao Yajun~2,Liu Bo~1 Department of Urology,Wuhan General Hospital of Military Command of Guanzhou,PLA,Wuhan 430070,China; 2.Depardement of Urology,Union Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology;Changes of bFGF in testis and epididymis of a rat model with oligoazoospermia/azoospermia induced by cyclophosphamide[J];中国男科学杂志;2010-02
Chinese Journal Full-text Database 10 Hits
1 LE Xiao-yan;YUAN Lin;LIN Shao-jie;TAO Ye-xing;GU Yi-peng;LIU Hua-zhong;College of Food Science and Technology,Guangdong Ocean University;Biochemistry Center,Guangdong Ocean University;;Preparation of squid ink polysaccharides and its protection against chemotherapeutic injury on testis[J];食品工业科技;2013-17
2 LUO Ping1,SHI Li-sha1,LIU Hua-zhong2,*(1.College of Food Science & Technology,Guangdong Ocean University,Zhanjiang 524088,Guangdong,China;2.Modern Biochemistry Centre,Guangdong Ocean University,Zhanjiang 524088,Guangdong,China);Antioxidant Effects of Polysaccharides from Squid Ink in Vitro[J];食品研究与开发;2013-08
3 GONG Qinqin1,ZHANG Changjun2,ZHANG Ying2,DONG Yifei2,RU Xue1,2,WANG Xiaoning1,2 1 The Research Center of Reproduction Medicine,The People's Hospital of Shiyan, Hubei University of Medicine,Hubei 442000,China 2 Hubei University of Traditional Chinese Medicine,Hubei 430065,China;Influence of cyclophosphamide on mouse sperm DNA and the function of curcumin interventio[J];中国性科学;2013-03
4 LE Xiao-yan1,XU Ze-xuan1,SHI Li-sha1,LIN Shao-jie1,YUAN Lin1,LIU Hua-zhong2(1.Faculty of Food Science and Techology,Guangdong Ocean University,Zhanjiang 524088,China; 2.Biochemistry Center,Guangdong Ocean University,Zhanjiang 524088,China);Effects of sepia ink polysaccharides on spermatogenesis injured by cyclophosphamide[J];中国海洋药物;2012-05
5 WANG Guang 1,ZHONG Jie-ping2,LIU Hua-zhong3,(1.College of Food Science&Technology,Guangdong Ocean University,Zhanjiang 524088,China;2.College of Science,Guangdong Ocean University,Zhanjiang 524088,China;3.Modern Biochemistry Center,Guangdong Ocean University,Zhanjiang 524088,China);Study on squid ink polysaccharides weakens the suppression of bone marrow induced by cyclophosphamide in rats[J];食品工业科技;2012-17
6 LIU Huazhonga,WANG Guangb,WU Jinlongb,SHI Lishab,ZHONG Jiepingc,PAN Jiangqiub(Guangdong Ocean University,a.Modern Biochemistry Center;b.School of Food Science & Technology;c.School of Science,Zhanjiang 524088,China);Amelioratory Effects of Sepia Ink Polysaccharides on Partial Internal Organs Injuried by Cyclophosphamide[J];中国现代应用药学;2012-02
7 GENG Hai-yun,CAO Li,CHEN Zhao-ying,CHEN Da-kun,TU Juan(Department of Nephrology,Children's Hospital of Capital Institute of Pediatrics,Beijing 100020,China);Long-term effects of cyclophosphamide and multiglycosides of tripterygium wilfordii on gonads in children[J];中国循证儿科杂志;2011-05
8 SHI Li-sha1,LIU Hua-zhong2,WU Jin-long1,CHEN Jiang-wei3,ZHANG Xu-ming3,ZHONG Jie-ping3*(1.College of Food Science & Technology,Guangdong Ocean University,Zhanjiang 524088;2.Modern Biochemistry Centre,Guangdong Ocean University,Zhanjiang 524088;3.College of Science,Guangdong Ocean University,Zhanjiang 524088);Extraction of polysaccharide in squid ink by enzymatic method[J];食品科技;2011-04
9 MIN Shi-gang1,WANG Guang1,ZHONG Jie-ping2,XIN Shi-xiong1,TU Jun-xiang3,WU Jin-long1,SHE Wen-hai1, PAN Jiang-qiu1,(1.College of Food Science & Technology,Guangdong Ocean University,Zhanjiang 524088,Guangdong,China; 2.College of Science,Guangdong Ocean University,Zhanjiang 524088,Guangdong,China;3.Zhanjiang Hua Tai Hospital,Zhanjiang 524088,Guangdong,China);Effect of Sepia Ink Polysaccharides on Peripheral Blood and Anti-oxidative Ability in Serum of Rats[J];食品研究与开发;2011-01
10 LUO Shao-bo1,JIA Jin-ming2,MA Wei-guo2,DONG Jia-chen2,JIAO Yong-zheng2,WANG Jia-hui3(1.Adrology Dept.of Genel Hospital of Air Force,PLA,Beijing 100142;2.Adrology Dept.of Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;3.The 2nd Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110034);To Cure the 178 Asthenospermia Males by Traditional Chinese Medicine Herbs"Huojingfang"[J];中国中医基础医学杂志;2010-08
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 SONG Laixin;ZHANG Changcheng;LIU Jing;HUANG Weifeng;YUAN Ding;ZHAO Haixia;Medical College of China Three Gorges University;;Effects of Total Flavonoids from Wuzi Yanzong Prescription on Cyclophosphamide-induced Apoptosis of Testicular Germ Cells of Mice[J];中药新药与临床药理;2017-01
2 WANG Feng;CHEN Ceng-ceng;YAN Yong-jian;;Research on health status of medical staffs with occupational exposure to antineoplastic drugs in China[J];中国职业医学;2016-05
3 LUO Shaobo;ZHANG Jinying;MENG Zhecheng;JIA Jinming;HUHaixiang;Department of Andrology,Guang'anmen Hospital South Area of China Academy of Chinese Medical Sciences;;Yijingfang increases the expression of CatSper1 and the concentration of Ca~(2+) in mice[J];空军医学杂志;2016-05
4 LYU Shijun;CHEN Dong;WANG Li;WANG Jiahui;Liaoning University of Traditional Chinese Medicine;Hainan Medical University;;Yijingfang on Expression of Tight Junction Protein in Testicular Sertoli Cells of Rats by Adenine Method[J];中华中医药学刊;2016-09
5 Wang Cheng;Yang Jinfeng;He Wenfei;Liu Yu;Department of Pediatric surgery,the Affiliated Hospital of North Sichuan Medical College;;ANIMAL EXPERIMENTAL STUDY ON THE EFFECT OF CURCUMIN ON REPRODUCTIVE DAMAGE INDUCED BY CYCLOPHOSPHAMIDE[J];广西医科大学学报;2016-04
6 MA Bao-liang;FU Sheng-jun;LU Jian-zhong;SHI Ting-kai;CHEN Si;TAO Yan;LIU Xiao;WANG Zhi-ping;Research Institute of Urology , Key Laboratory of Gansu Province for Urological Diseases , Clinical Center of Gansu Province for Nepho-Urology,Lanzhou University Second Hospital;Department of Laboratory Medicine,Lanzhou University Second Hospital;;Effects and action mechanisms of apocynin in the treatment of oligoasthenozoospermia in the mouse[J];中华男科学杂志;2016-07
7 HUANG Wei-feng;ZHANG Chang-cheng;LIU Jing;SONG Lai-xin;PENG Ben;ZHAO Hai-xia;Medical College of China Three Gorges University;;Protective Effect of Wuzi Yanzong Prescription on Apoptosis in Germ Cells of Mice Induced by Cyclophosphamide[J];中药材;2016-05
8 JIANG Mao-wang;GAO Xiao-lan;HAN Qing-xi;PENG Rui-bing;JIANG Xia-min;School of Marine Sciences,Ningbo University;;Study on condition optimizing of extraction technique of squid ink polysaccharide from Sepia pharaonis by response surface methodology[J];食品工业科技;2016-18
9 LIU Danwei;PAN Wei;XU Guobing;YANG Guozhen;Department of Medical Laboratory,Guizhou Medical University;Department of Medical Laboratory,Beijing Cancer Hospital;;Study on Antagonistic Effect of S1P on Toxicity Damage to Male Mice' Reproductive Cells by Cyclophosphamide[J];贵阳医学院学报;2016-05
10 WANG Shiping;SUN Lijiang;LI Yanjiang;LI Bin;WANG Xinsheng;Department of Urology,The Affiliated Hospital of Qingdao University;;THE EXPRESSION OF CATSPER1 IN SPERM OF PATIENTS WITH VARICOCELE[J];青岛大学医学院学报;2016-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved