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《National Journal of Andrology》 2012-05
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Nicotine reduces endogenous CO concentration and NOS activity in rat corpus cavernosum

XU Hui1,QIN Wen-bo2,YU Man1,WANG Zhi-yong1,MA Ying-hui3 1.Department of Urology,3.Department of Ophthalmology,The Affiliated Hospital of Chengde Medical College,Chengde,Hebei 067000,China;2.Department of Urology,Dental Hospital of Jiamusi University,Jiamusi,Heilongjiang 154002,China  
Objective: To observe the effects of nicotine on endogenous carbon monoxide(CO) concentration and nitric oxide synthase(NOS) activity in the corpus cavernosum of adult male rats,and explore the possible mechanism of cigarette smoking affecting erectile dysfunction.Methods: Forty adult male rats were equally divided into three treatment groups to receive subcutaneous injection of nicotine at 0.5 mg/kg pre d for 1,2 and 3 months,and a control group to receive saline only.After treatment,the corpus cavernosum was harvested for detection of CO concentration by modified two-wavelength spectrophotometry and NOS activity by improved Griess measurement.Results: CO concentration and NOS activity were decreased by 9.05 and 13.37%,respectively,after 1 month of nicotine injection(P0.01),16.47 and 22.5% after 2 months(P0.01),and 22.99 and 31.74% after 3 months(P0.01),as compared with(13.664±0.404) umol/mg prot and(9.721±0.470) U/mg prot in the control group.Conclusion: Nicotine can reduce endogenous CO concentration and NOS activity in the corpus cavernosum of adult male rats,which suggests the involvement of endogenous CO and NOS in the pathophysiological process of smoking-induced erectile dysfunction.
【CateGory Index】: R363
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 M. ARABI, B. SHAREGHI Department of Biology, Andrology Unit, Shahrekord University, Shahrekord-88186, POB 115, Iran;Anti-fertility Effect of Nicotine[J];Nationlal Journal of Andrology;2005-05
2 GUO Yu-gang~(1),QIN Wen-bo~(1),SONG Wen-jun~(1), WANG Shu-qiu~(2) 1.Department of Urology,the First Affiliated Hospital,2.Department of Pathophysiology,College of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154002,China;Effect of Endogenous Carbon Monoxide on the Smooth Muscle Function of Dog Penile Corpus Cavernosum in Vitro[J];National Journal of Andrology;2006-08
3 QIN Wen-bo1,WANG Shu-qiu2,LI Ming1,KANG Yu-ming3,GUI Shi-liang1,CHI Bao-jin11.Department of Urology,The First Affiliated Hospital,2.Department of Pathophysiology,College of Basic Medical Sciences,Jiamusi University,Jiamusi,Heilongjiang 154007,China;3.Department of Physiology,Shanxi Medical University,Taiyuan,Shanxi 030001,China;Aging Reduces Contents of Endogenous CO,cAMP and cGMP in Rat Penile Tissues[J];National Journal of Andrology;2009-02
4 LIU Xiao-bing,WU Tian-peng,ZHAN Yun-yun,WANG Zhao-yangDepartment of Urology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China;Cigarette smoke extract reduces NOS activity and CX43 expression in the corporal cavernosum[J];National Journal of Andrology;2011-04
5 HAN Ying, Murata Yuhji, Itoh Jugoh, et al. Department of Gastroenterology, Beijing Army General Hospital, Beijing, 100700, China;Effect of long-term nicotine on oxazolone induced murine colitis model[J];Chinese Journal of Digestion;2001-08
6 Zeng Jinsheng,Ye Qifa Research Institute of Organ Transplantation, Tongji Hospital, Tongji Medical college of Huazhong University of Science and Technology, Wu han 430030$$$$;AN IMPROVED TWO-WAVELENGTH SPECTROPHOTOMETRY FOR MEASURING CARBON MONOXIDE IN PLASMA[J];China Journal of Modern Medicine;2002-16
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Li (Jinzhou Normal College, Jinzhou 121000);Probe into Mechanism of How Smoking Affects Sports Results[J];Journal of Beijing Teachers College of Physical Education;2003-01
2 PU Jun 1,CHENG Zai xian 2 (1.Department of Reproduction of Medical Science,Chongqing University of Medical Sciences,Chongqing 400016,China; 2.Department of Urology,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);The effect of cryopreservation on the ability of fertilization of human sperm[J];Chongqing Medical Journal;2004-05
3 Wang Gui-Ping,Li Ming,Zhang Wan-Feng,et al, (Department of Urology,Longnan Hospital of Daqing City,Daqing 163453,China);The Study about cAMP and cGMP in the Penile Corpus Cavernous of Hyper Homocysteine Rats[J];Chinese Journal of Medicinal Guide;2011-11
4 XIAO Peng,GAO Hong,YAN Yu-ling,ZHOU Ming-tao,ZHOU Hui,LIU Lei (College of Animal Science and Technology,Yunnan Agricultural University,Kunming,Yunnan,650201,China);Progress on the Endogenous Carbon Monoxide[J];Progress in Veterinary Medicine;2009-05
5 Zhang Yingao, Huang Qiang, Guo Qianghen, et al. Department of Surgery, the Affiliated Hospital of Enshi Medical College Enshi 445000;Clinical Investigation on Intracavernous Injection of Papaverine Compound of Premature Ejaculation[J];;1998-03
6 LIU Qi-rong (Infertility Research Stndio, Affiliated Hospital of Hubei Institute for Nationalities, Enshi 445000);Analyses of 403 Male Infertilities in Enshi Prefecture[J];JOURNAL OF HUBEI INSTITUTE FOR NATIONALITIES MEDICAL EDITION;2000-03
7 YANG Jian1,CUI Shu-lan2,LONG You-ming1,CHEN Ken1,WANG Hui3,WANG Nian-lin1,XIE Wen-rui1,LIU Jun-jun1 (1.Clinical Medical School,Guangzhou,Guangdong 510310,China;2.Affiliated Outpatient Department,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China);Experimental study on micromolecule polypeptide combining with NEMO-binding domain treating on rats of ulcerative colitis[J];Journal of Guangdong Pharmaceutical College;2009-02
8 LIU Yun-ke,CHEN Jing-song,GUO Cai-jiao (Women and lnfants Hospital of Guangzhou,Guangzhou 510180,China);Analysis and Determination on the Content of Trace Elements in 174 Inferile Men with Seminal Plasma[J];Trace Elements Science;2001-04
9 Sunaibin,Dazhu People's Hospital.(635100);Suprapubic transvesical prostatectome of broad and male sexual function[J];Foreign Medicines-urinary System;2005-S1
10 MA Ling,ZHANG Yuan\|zhen,HU Lun\|ying (Zhong Nan Hospital,Wuhan University,Wuhan 430071 China);Study on Effects of Constant Magnetic Fields on Sperm Toxicity of Mice[J];Industrial Health and Occupational Diseases;2002-01
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Yu-Gui CUI 1, Yue JIA 1, Fu-Song DI 1, Xing-Hai WANG 2 (1.Key Labotory, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; 2.Jiangsu Institute for Family Planning, Nanjing, Jiangsu 210036, China);Androgen Replacement Therapy for Hypogonadal Men[J];Acto andrologica Sinica;2003-03
2 LI San-xiang,DAI Yu-tian Department of Urology,Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical College,Nanjing,Jiangsu 210008,China;Effects of Penile Vasoactive Mediators on the Development of Erectile Dysfunction[J];Nationlal Journal of Andrology;2005-11
3 HU Hai-long,HAN Rui-faTianjin Institute of Urology,Tianjin 300211,China;The Concentration of HO-2 and CO in Rat Penile Tissue of Different Ages[J];National Journal of Andrology;2006-05
4 GUO Yu-gang~(1),QIN Wen-bo~(1),SONG Wen-jun~(1), WANG Shu-qiu~(2) 1.Department of Urology,the First Affiliated Hospital,2.Department of Pathophysiology,College of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154002,China;Effect of Endogenous Carbon Monoxide on the Smooth Muscle Function of Dog Penile Corpus Cavernosum in Vitro[J];National Journal of Andrology;2006-08
5 LI Zheng, JIANG Jian-hang, ZHANG Xian-sheng, XIANG Zu-qiong, HAN Yin-fa, WANG Yi-xin (Shanghai Institute of Andrology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China);Expression and Significance of Cx43 and nNOS mRNA in the Corpus Cavernosum of Patients with Erectile Dysfunction[J];Acta Universitatis Medicinalis Secondae Shanghai;2005-04
6 GUO Jian Zeng,ZHOU Qi Xin (Department of Pharmacology,Chongqing University of Medical Sciences,Chongqing 400016);The Research into Functions of Heme Oxygenase System in Brain[J];Progress In Physiological Sciences;2002-01
7 SHI Yuan; LI Hua - Qiang; PAN Jie, JIANG Dong - Bo; TAN Shi - Wen; YAO Zhong -Kai; SHEN Ji - Gao (Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042);Changes of endogenous carbon monotide in plasma and aorta in rabbits with endotoxin shock[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1999-09
8 WANG Guan-song, QIAN Gui-sheng, YANG Xiao-jing, CHEN Wei-zhong (Institute of Respiratory Disease, Xingiao Hosptial, Third Military Medical University, Chongqing 400037,China)[;Effect of carbon monoxide on hypoxic proliferation of rat pulmonary arterial smooth muscle cell[J];Chinese Journal of Pathophysiology;2000-02
9 Zeng Jinsheng,Ye Qifa Research Institute of Organ Transplantation, Tongji Hospital, Tongji Medical college of Huazhong University of Science and Technology, Wu han 430030$$$$;AN IMPROVED TWO-WAVELENGTH SPECTROPHOTOMETRY FOR MEASURING CARBON MONOXIDE IN PLASMA[J];China Journal of Modern Medicine;2002-16
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