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《Acta Academiae Medicinae Neimongol》 2003-02
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THE IMPLICATION OF MULTIPLE ASSAYS IN DIFFERENTI-ATION OF BENIGN FROM MALIGNANT HYDROTHORAX

YANG Jing ping, SUN De jun, WANG Xiu xiang, et al. (Department of Respiratory Disease, Third Affiliated Hospital, Inner Mongolia Medical College, Baotou 014010 China)  
Objective: To discuss the role of pleural biopsy and detecting pleural level of CA 50 \, TSA\, SF\, CEA\, chromosome analysis in differentiation of benign from malignant hydrothorax. Methods: 40 patients of tuberculous hydrothorax (group A) and 34 patients of malignant hydrothorax (group B) were taken pleural biopsy and detected the pleural level of CA 50 ?TSA?CEA?SF with radioimmunoassay, routine chromosome preparation, and compared the difference of the level of above\|mentioned markers, estimated the positive rate and specific of above\|mentioned markers. Results: The positive rate of pleural biopsy in patients with tuberculous and malignant hydrothorax were 60% and 50%. The values of CA 50 ?TSA?CEA?SF and chromosome analysis in group B were significantly higher than those in group A (P0 001 and P0 01). The sensitivity of using a combination of the CA 50 ?TSA?CEA?SF?chromosome analysis assays and a combination of the CA 50 ?CEA?chromosome analysis assays were increased to 88% and 76%, there was significant difference (P0 01). The specific of combination assay of 3 markers was 95%, it was significantly higher than that of single assay (P0 05). The specific of combination assay of 3 markers was significantly heiger than that of 5 markers (P0 01). Conclusion: The results suggest that determination of CA 50 ?TSA?CEA?SF and chromosome analysis are better for the differentiating benign from malignant hydrothorax. The missed diagnosis rate of combination assay of 5 markers may produce a significant decrease in patients with malignant hydrothorax. CEA\, CA 50 in combination with chromosome analysis assay may be a better indicator for screening the malignant hydrothorax.\;
【CateGory Index】: R447
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