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《Acta Academiae Medicinae Neimongol》 2004-04
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DISEASE MODEL OF CHRONIC RENAL FAILURE IN RATS MADE BY ADENINE

ZHOU Jing, AI Min, WANG Zhao-yang (Department of Pharmacology, Inner Mongolia Medical College, Hohhot 010059 China)  
Objective: To make disease model of chronic renal failure (CRF) in rats by adenine. Methods: We fed the Wistar rats 200 mg/kg adenine per day and kept feeding them with the same dosage for 24 days. We observed the general health conditions and tested hematologic and biochemical indices (RBC, HGB, HCT, BUN, Scr, Ca 2+, P 5+) and changes in histopathology. Results: The disease model had the CRF symptoms of reduced levels of RBC, HGB, HCT, Ca 2+ and increased levels of BUN, Scr and P 5+. In histopathology, the disease model had main damage in renal tubules. Conclusion: The adenine was suitable for making disease model of CRF in rats.
【CateGory Index】: R-332
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