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《Inner Mongolia Medical Journal》 2010-09
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Inhibitory Effects of Taurine on the Expression of NF-κB During Acute Lung Injury in Rats

TIAN Xian-feng,LIU Yong-wang(Department of Emergency,The Central Hospital of Baotou City,Baotou 014040 China)  
Objective:To investigate the protective effect of taurine(Tau) on lung tissues during acute lung injury(ALI) in rats and its possible mechanism.Methods: All rats were randomly divided into four groups: Control group,Lipopolysaccharide(LPS)group,dexamethasone(DEX) and Tau treatment group.Myeloperoxidase(MPO) activity、superoxide dismutase(SOD) activity and malonaldehyde(MDA) content of lung tissues were detected at 6,12 and 24h after intratracheal instillation in each group.In addition,the expression of nuclear factor-kappa B(NF-κB)were observed through immunohistochemistry staining in lung tissues.Results: Compared with Control group,SOD activity decreased significantly in LPS group(P0.01),but MPO activity,MDA content and the expression of NF-κB increased obviously(P0.01);the administration of Tau and DEX mitigated above changes significantly(P0.05 or 0.01).Conclusion: Tau possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the activition of NF-κB.
【CateGory Index】: R285.5
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