Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Nantong University(Medical Sciences)》 2008-04
Add to Favorite Get Latest Update

Hepatic radioembolization with epirubicin mixed microspheres for the treatment of hepatocellular carcinoma

LI Wenhui LUO Jianjun YAN Zhiping (The Interventional Therapy Center of the Third Hospital of Yancheng,Yancheng 224001;Department of Radiology,Zhongshan Hospital,Fudan University)  
Objective:To evaluate the clinical efficacy of epirubicin mixed micmspheres in the treatment of hepatocellular carcinoma (HCC) through hepatic artery perfusion and embolism.Methods:136 subjects were divided randomly into two groups (68 cases in either group):treatment group (Group A),in which the microglobule (TACE and epirubicin mixed microspheres) was given and control group(Group B),in which the first therapy plan(TACE) was implemented alone.By seldinger's procedure, super-selctive catheterization was performed to the end of proper artery for instilling the epirubicin mixed microspheres,maked by 10~60 mg epirubicin mixed with 0.5~2.0 ml microspheres (300~500μm).The tumor size,AFP,leucocyte count,liver function,and correlated complications were observed before and after treatment.Results:After treatment,the average size of tu- mor decreased by (81±3)% in group A;(70±3)% in group B.The necrotic percentage of tumor was (76±8)% in group A;(61±8)% in group B.The incidence of AFP was decresed by (88±3)% in group A;(70±3)% in group B;As to the the one year survival rate,group A was superior to group B.But the toxicity of treatment group was significantly higher than that in control group (P0.05).Conclusion:Superselective intraarterial radioembolization with epirubicin mixed microspheres is effective and safe for treatment of hepatocellular carcinoma,but the dosage of mixed microspheres should be chosen carefully because of the hepatic dysfunction.
【CateGory Index】: R735.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Yue-wei,LI Chuang,TANG Rong-bin,GAO Wen-bin,JI Xue-ning Department of Interventional,Zhongshan Hospital of Dalian University,Dalian 116001,China;Therapeutic observation of huge primary hepatoma embolization with gelatin sponge particles combined with epirubicin[J];Contemporary Medicine;2009-29
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Yan-Bin, CHEN Min-Hua, YAN Kun, YANG Wei, DAI Ying, YIN Shan-Shan Department of Ultrasound, School of Oncology, Peking University, Beijing, 100036, P.R.China;Quality of Life of Primary Hepatocellular Carcinoma Patients after Radiofrequency Ablation[J];Chinese Journal of Cancer;2005-07
2 QI Huai-hua,ZHAO Hui,LIU Yuan-ting,et al (Department of Oncology,People's Hospital,Tangshan 063000,China.);PUMP IMPLANTATION CHEMOTHERAPY FOR ADVANCED HEPATOCELLULAR CARCINOMA[J];Journal of Chengde Medical College;2006-03
3 GUAN Bin,TANG Yong,HOU Ting-quan,et al.(Department of Radiology,Hechuan People's Hospital,Chongqing 401520,China);Clinical study of double intervention therapy for moderate or advanced liver cancer[J];Chongqing Medicine;2006-22
4 WU Hong-zhang,ZHAO Qiang,CHENG Li-xin,et al.The People's Hospital of Taishan,Taishan,529200,China;A Study on Preventing the Recurrence of Hepatocellular Carcinoma By Hepatectomy with HACE and PVCE[J];Journal of Chinese Physician;2001-10
5 SONG Lei1,L Shen (1.Department of Oncology,2.Medical Center,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China);Possibility of VEGF as a marker to evaluate effectiveness of intervention therapy to hepatorcellular carcinoma[J];Journal of Dalian Medical University;2008-03
6 WANG Jingbing,FENG Gansheng,LIANG Huimin,et al.Department of Interventional Radiology,Xiehe hospital,Tongji Medical college,Huazhong Science and Technology University,Wuhan 430022;Percutaneous microwave coagulation therapy for malignant hepatic tumor:preliminary study[J];Radiologic Practice;2003-01
7 Pan Wanneng,Mao Shengming,Li Rongxiang,et al. Department of Hepatobiliary Surgey,The Fifth Hospital Panzhihua, Panzhihua,617000;TREATMENT OF UNRESECTABLE PRIMARY HEPATIC CARCINOMA WITH EMBOLIZATION AND CHEMOTHERAPY VIA HEPATIC ARTERY AND PORTAL VEIN[J];Journal of Hepatobiliary Surgery;2001-06
8 LI Qi gen,LU Jun hua,ZHANG Yong jie,et al. The Eastern Hepatobiliary Hospital,Shanghai 200438;The analysis of pleuritis caused by Ⅱ-stage right robe HCC resection following TAEC[J];Journal of Hepatopancreatobiliary Surpery;2001-03
9 BI Yong-hao1,FANG Fu-yi1,MO Qin-guo2,LIANG An-min2.1.The Second People's Hospital of Qinzhou City (Qinzhou 535000);2.Tumor Hosital of Guangxi (Nanning 530021),China.;Treatment of combined trans-arterial chemoenbolization and percutaneous ethanol injection for hepatocellular carcinoma-a report of 112 cases[J];Guangxi Medical Journal;2005-12
10 Pei Shengjian,Sun Kang,Li Weidong,Zhang Jinshui (Department of CT Room,Zhoucun People's Hospital,Zibo 255300,China);The Clinical Analysis of Chemoembolization and Percutaneous Ethanol Injection in Treatment of Moderate or Advanced Liver Cancer[J];Journal of Basic and Clinical Oncology;2007-06
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 ZHANG Fan,SHANG Hai-feng,ZHANG Jing Hebei General Hospital,Shijiazhuang 050071,China;The Serious Complication During Transcatheter Arterial Chemoembolization of hepatocellular carcinoma——Cerebral Lipiodol Embolism(CLE)[J];Contemporary Medicine;2009-05
2 PENG Huai-yu,REN Xin-le,WANG Meng,YIN Jin-lin Department of Intervention, Third Affiliated Hospital of Henan University of Science and Technology Division, Henan 471003 China;Evaluation on therapeutic effect in hepatoma of embolization with PVA granula[J];Contemporary Medicine;2009-17
3 Timm D Kirchhoff, Joerg S Bleck, Arne Dettmer, Ajay Chavan, Herbert Rosenthal, Sonja Merkesdal, Bernd Frericks, Lars Zender, Nisar P Malek, Tim F Greten, Stefan Kubicka, Michael P Manns and Michael Galanski Department of Diagnostic Radiology , Department of Gastroenterology, Hepatology, and Endocrinology , Hannover Medical School, Germany; Department of Diagnostic and Interventional Radiology, Klinikum Oldenburg, Germany ; Division of Rheumatology, Hannover Medical School, Germany; Department of Radiology and Nuclear Medicine, Campus B.F-Charité-University Medicine, Berlin, Germany;Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival[J];国际肝胆胰疾病杂志(英文版);2007-03
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Jingbing,FENG Gansheng,LIANG Huimin,et al.Department of Interventional Radiology,Xiehe hospital,Tongji Medical college,Huazhong Science and Technology University,Wuhan 430022;Percutaneous microwave coagulation therapy for malignant hepatic tumor:preliminary study[J];Radiologic Practice;2003-01
2 XIAO Enhua, HU Guodong, LIU Pengcheng,et al. Department of Hepatobiliary, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, Guangdong Province 510060, P.R.China;The Effect of Chemoembolization on nm23/ndpk Gene Expression of Primary Hepatocellular Carcinoma[J];Journal of Clinical Radilolgy;2000-11
3 LI Zhen, HU Daoyu, CHU Qian,et al. Department of Radiology, The Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, P. R. China;Experimental Observation of Hepatic Cell Cycle Alteration after Transarterial Chemoembolization for Hepatic Carcinoma[J];Journal of Clinical Radiololgy;2003-04
4 GONG Gaoquan, WANG Xiaolin, ZHOU Kangrong,et al. Department of Radiology, The Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;Metallic Stent Treatment of Portal Cancerous Thrombus in Primary Hepatic Carcinoma: A Report of 19 Cases[J];Journal of Clinical Radiololgy;2003-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved