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《Journal of Nantong University(Medical Sciences)》 2008-04
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Hepatic radioembolization with epirubicin mixed microspheres for the treatment of hepatocellular carcinoma

LI Wenhui LUO Jianjun YAN Zhiping (The Interventional Therapy Center of the Third Hospital of Yancheng,Yancheng 224001;Department of Radiology,Zhongshan Hospital,Fudan University)  
Objective:To evaluate the clinical efficacy of epirubicin mixed micmspheres in the treatment of hepatocellular carcinoma (HCC) through hepatic artery perfusion and embolism.Methods:136 subjects were divided randomly into two groups (68 cases in either group):treatment group (Group A),in which the microglobule (TACE and epirubicin mixed microspheres) was given and control group(Group B),in which the first therapy plan(TACE) was implemented alone.By seldinger's procedure, super-selctive catheterization was performed to the end of proper artery for instilling the epirubicin mixed microspheres,maked by 10~60 mg epirubicin mixed with 0.5~2.0 ml microspheres (300~500μm).The tumor size,AFP,leucocyte count,liver function,and correlated complications were observed before and after treatment.Results:After treatment,the average size of tu- mor decreased by (81±3)% in group A;(70±3)% in group B.The necrotic percentage of tumor was (76±8)% in group A;(61±8)% in group B.The incidence of AFP was decresed by (88±3)% in group A;(70±3)% in group B;As to the the one year survival rate,group A was superior to group B.But the toxicity of treatment group was significantly higher than that in control group (P0.05).Conclusion:Superselective intraarterial radioembolization with epirubicin mixed microspheres is effective and safe for treatment of hepatocellular carcinoma,but the dosage of mixed microspheres should be chosen carefully because of the hepatic dysfunction.
【CateGory Index】: R735.7
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