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《ACTA ACADEMIAE MEDICINAE NANTONG》 1994-01
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DETERMINATION OF IMMUNOCOMPETENCE IN PERI-OPERATIVE PATIENTS WITH MALIGNANT TUMOR OF THE DIGESTIVE SYSTEM

Xu Meirong; et al(Department of General Surgery, Affiliated Hospital of Nantong Medical College)  
The treatment and prognosis of the tumors of the digestive system are closely related to the biological status of the tumor immunity, especially to the T lymphocyte-mediated cellular immunity. We determined the T lymphocyte subsets in the peripherial blood samples collected from 25 normal controls and 30 patients with malignant tumors of the digestive system before and after operaiton. Before operation, the immunocompetence was suppressed in tumor patients, which was characterized by significantly decreased CD3, CD4subsets, increased CD8subset and consequently decreased CD4/CD8ratio(P0.01). Ten days after operation,CD,and CD.were increased, CD8 was decreased, and CD4/CD8ratio was increased markedly, however, these values except CD8were still significantly lower than those in normal controls. These data suggested that the immunocompetence in patients with malignent tumors were remarkably suppressed when exposed to the burden of tumor, and restored to some degree after removal of the tumor. However, immunoassistant therapy is necessary for improvement of the immunocompetence and increase of the curative rate.
【CateGory Index】: R735.03
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