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《Chinese Journal of Cerebrovascular Diseases》 2006-05
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Effects of berberine on atherosclerosis and plasma levels of lipid in atherosclerotic rabbits

ZUO Yan-fang,GUO Yi,JIANG Xin;LI Fang-ming,WANG Qi-zhang. Department of Neurology,the Second Clinical Medical College of Jinan University ,Shenzhen 518020,ChinaCorresponding author:GUO Yi  
Objective To examine the effects of berberine on atherosclerosis and plasma levels of lipid in rabbits. Methods 18 male New Zealand rabbits were randomly divided into 3 groups: control group, untreated cholesterol-fed group, and berberine treated group, which were fed for 12 weeks. After 12 weeks, plasma levels of total cholesterol(TC)、triglycerides(TG)、high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were measured enzymatically by automatic facilities and the aorta was harvested for pathologic morphology observation. Results The aorta plaque / intima size (P/ I) was 0%、(59.6±13.7)% and (36.3±16.5)% in control, untreated cholesterol-fed group and berberine treated group respectively by pathologic morphology observation (P0.01). The maximum plaque thickness, the average plaque thickness, the degree of aortic stenosis and the proportion of the intimal circumference occupied by atheroma of 3 groups were different from each other significantly (P0.01). Plasma levels of TC and HDLC in berberine treated group were decreased significantly (by 28.88% and 40.94% respectively) compared with that in untreated cholesterol-fed group (P0.01). Plasma levels of HDLC and TG in berberine treated group showed no difference from untreated cholesterol-fed group (P0.05). Conclusion Berberine can decreased plasma levels of TC and HDLC and suppress the progression of atherosclerosis and stabilize the plaque in experimental atherosclerosis.
【CateGory Index】: R285
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