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Metheylene blue prevents oxytocin?induced penile erection

Zhou Ruijin,Liu Zhonghua,Qi Tianwei,et al Department of Urology,Henan Province People's Hospital, (Zhengzhou 450003)  
For illustrating the central penile erection mechanism,the effect of metheylene blue on oxytocin?induced penile erection in 20 rabbits was studied.The basal coporal cavernosal pressure (CCP)was 2.5±1.8 mmHg.Oxytocin was injected intracerebroventricularly(i.c.v.)in doses 2 μg、5 μg and 10 μg.The CCP were rising periodically and rhythmically at the dose 5 μg or 10 μg.The maximal CCP were 4.5±3.5 mmHg and 31±10 mmHg,respectively.Oxytocin?induced penile erection was prevented by methylene blue,an inhibitor of guanylate cyclase.The present results show indirectly that NO plays a key role on the penile erection.
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