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《Chinese Journal of Andrology》 2003-05
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Effects of flavonoids from herba epimedii on the reproductive system in male rats

She Bairong, Qin Danian, Wang Sheng, et al School of Medicine, Shantou University, Shantou 515041, China  
Objective To study the effects of the flavonoids extracted from the Herba Epimedii (FHE) on the reproductive and endocrine functions in male rats. Methods (1) Effect of FHE on the reproductive organs was assessed in immature rats. Rats were administered FHE through gastric garage for 7 days and the weights of pituitary gland, testis, epididymis and seminal vesicle were then observed; (2) To observe the effect of FHE on the reproductive endocrine function:same dose level of FHE was given to male rats of different age groups for 7 days;on day 8, the plasma testosterone (T),estradiol(F_2) and LH were determined by RIA; (3) To observe the effect of FHE on T secretion was assessed in vitro on Leydig cell culture. Results FHE increased the weights of pituitary gland, epididymis, and seminal vesicle, and stimulated T and LH secretion in immature rats. The increase of T secretion was also observed in vitro. Conclusions FHE invigorates the reproductive system and reproductive endocrine function in male rats.
【Key Words】： Flavone Herba Epimedii Leydig cell male rats
【Fund】： 广东省中医药局科研基金(No 102057)
【CateGory Index】： R285
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