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《Chinese Journal of Andrology》 2004-01
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Toxic effects of cadmium chloride on the reproductive function and reproductive organs of male mice

Jin Longjin, Zhang Junming, Lou Zhefeng, et alDepartment of Biology, Wenzhou Medical College, Wenzhou 325027, China  
Objective To study the toxic effects of cadmium chloride on the reproductive organs, germ cell andreproductive function. Methods Male mice of 4 weeks were administered by cadmium chloride (0.5mg/kg, 2mg/kg,8mg/kg. Wt) into the abdominal cavity for 10 times. On the 50th day, the males were mated with females non-exposed(1:2). The pregnant and ectopic pregnancy rate of these females, amount of their offsprings, body weight of theiroffsprings, and testis index of male mice, sperm count, sperm motility, incidence of teratospermia and abnormalmeiosis were observed. Results The testis index of 2mg/kg and 8mg/kg group was lower than that of normal group and0.5mg/kg group (p0.05).There was testicular maldevelopment, azoospermia and male infertility in 8mg/kg group and2 mg/kg group. The pregnant rate of cadmium chloride group(2mg/kg) was lower than that of normal group (p0.05) for 1week and 3 weeks. The differences between ectopic pregnancy rate of each cadmium chloride group and that of normalgroup were not statistically significant (p0.05). The differences between sperm count, sperm motility, incidence ofteratospermia of 0.5mg/kg cadmium chloride group and those of normal group were not statistically significant (p0.05).Conclusions The pregnancy rate was decreased by 2mg/kg cadmium chloride or up is possible related to testisdevelopment and azoospermia.
【Fund】: 浙江省温州市科技基金资助项目
【CateGory Index】: R114
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