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《Chinese Journal of Andrology》 2004-01
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Toxic effects of cadmium chloride on the reproductive function and reproductive organs of male mice

Jin Longjin, Zhang Junming, Lou Zhefeng, et alDepartment of Biology, Wenzhou Medical College, Wenzhou 325027, China  
Objective To study the toxic effects of cadmium chloride on the reproductive organs, germ cell andreproductive function. Methods Male mice of 4 weeks were administered by cadmium chloride (0.5mg/kg, 2mg/kg,8mg/kg. Wt) into the abdominal cavity for 10 times. On the 50th day, the males were mated with females non-exposed(1:2). The pregnant and ectopic pregnancy rate of these females, amount of their offsprings, body weight of theiroffsprings, and testis index of male mice, sperm count, sperm motility, incidence of teratospermia and abnormalmeiosis were observed. Results The testis index of 2mg/kg and 8mg/kg group was lower than that of normal group and0.5mg/kg group (p0.05).There was testicular maldevelopment, azoospermia and male infertility in 8mg/kg group and2 mg/kg group. The pregnant rate of cadmium chloride group(2mg/kg) was lower than that of normal group (p0.05) for 1week and 3 weeks. The differences between ectopic pregnancy rate of each cadmium chloride group and that of normalgroup were not statistically significant (p0.05). The differences between sperm count, sperm motility, incidence ofteratospermia of 0.5mg/kg cadmium chloride group and those of normal group were not statistically significant (p0.05).Conclusions The pregnancy rate was decreased by 2mg/kg cadmium chloride or up is possible related to testisdevelopment and azoospermia.
【Fund】: 浙江省温州市科技基金资助项目
【CateGory Index】: R114
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【References】
Chinese Journal Full-text Database 4 Hits
1 QIU Ji(Office of Scientific Research,Huzhou Vocational& Technological College,Huzhou 313000,China);Review of the Male Reproductive Toxicity by Cadmium[J];Journal of Huzhou Vocational and Technological College;2008-03
2 Long-Jin Jin*, Zhou-Xi Fang1, Zhe-Feng Lou1, Chan Zhang1, Xi-Wen Chen2 (College of Life Sciences, Key Research Laboratory for Medical Genetics of Zhejiang; 1Central Laboratory of Biology; 2Laboratory Animal Center; Wenzhou Medical College, Wenzhou 325035, China);Effects of Cadmium on the Ultrastructure of Mice Sperm and Spermatogenic Cell and Gene Expression of bcl-2,bax in Male Mice[J];Chinese Journal of Cell Biology;2006-03
3 LI Xin-hong,WENG Zhi-ying,LI Qin,CHEN Zhen-liang,XU Yun(Shanghai Key Laboratory of Veterinary Biotechnology,College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China).;Effects of cadmium on testis spermatocyte apoptosis and epididymis mature spermatozoa quality of mice[J];Chinese Journal of Applied Ecology;2010-04
4 JIN Long-jin,FANG Zhou-xi,ZHANG Chan,LOU Zhe-feng,DONG Jie-ying,CHEN Xi-wen.Central Laboratory of Biology,Wenzhou Medical College,Wenzhou,Zhejiang Prouince 325027,China;DNA damage,Bcl-2、Bax expression and ultrastructure change in spermatogenic cell of mice exposed to cadmium[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2005-04
【Citations】
Chinese Journal Full-text Database 6 Hits
1 Li Jianxiu; Wang Xiaomei(Handan Medical College, Handan, Hebei 056002 China);EFFECT OF CADMIUM CHLORIDE ON MICE SPERM[J];INDUSTRIAL HEALTH AND OCCUPATIONAL DISEASES;1997-04
2 CHEN Min,XIE Jimin,GAO Xiaoqin,et al (Zhenjiang Medical College,Zhenjiang 212001,China);Effect of Camdium on Testicular Toxicity in Mice[J];INDUSTRIAL HEALTH AND OCCUPATIONAL DISEASES;2000-05
3 Li Jisheng,\ Yi Jianhua,\ Wang Chao,\ Xu Pengxiao,et al. Department of Neurobiology, Chinese People's Armed Police Force Medical College, Tianjin\ 300162,China;Effect of cadmium on apoptosis of spermatogenic cells of rat testis and the protection effect of zinc against it[J];JOURNAL OF HYGIENE RESEARCH;2000-03
4 Chen Hua-yue;Quantitative Histological Effects of Cadmium on Testis and Epididymis of the Mice[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;1990-03
5 Yang Jianming*,Wu Xiangdong,Jin Taiyi,et al.*Department of Occupational Health,Shanghai Medical University,Shanghai 200032 ;Effects of cadmium on lipid peroxidation of Leydig cells of rat testis in vitro[J];CHINESE JOURNAL OF INDUSREIAL HYGIENE AND DCCUPATIONAL DISEASES;1998-01
6 Yang Jianming*,Wu Xiangdong,Jin Taiyi,et al.*Department of Occupational Health,Shanghai Medical University,Shanghai 200032;Study of cadmium toxicity on sexual gland and accessory glands[J];CHINESE JOURNAL OF INDUSREIAL HYGIENE AND DCCUPATIONAL DISEASES;1998-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Li,LI Jie,LIU Jian-jun,XU Xin-yun,YANG Lin-qing(Shenzhen Center for Disease Control and Prevention,Shenzhen 518020,Guangdong,China);Effects of cadmium chloride on the expression of PKCα in NRK cells and the biological effect of PKC inhibitor[J];Carcinogenesis,Teratogenesis & Mutagenesis;2010-03
2 HUANG Qiu-chan et al(Department of Chemistry and Life Science,Nanning Teachers College,Longzhou,Guangxi 532400);Review on the Toxicological Effect and the Mechanism of Cadmium to Human Health[J];Journal of Anhui Agricultural Sciences;2007-09
3 ZHANG Xian-long et al(College of Environment and Bio-engineering,Shenyang College of Chemical Technology,Shenyang,Liaoning 110142);Preliminary Study on Accumulation Characteristics and Speciation of Cd in Soybean[J];Journal of Anhui Agricultural Sciences;2010-02
4 ZHANG Hao 1 SHAO Wei 2 LI Ya-lin 1 DUAN Xiao-qin 3 (1 Yili Vocational and Technical College,Yining Xinjiang 835000;2 Xinjiang Agricultural University; 3 Xinjiang Agricultural Vocational Technical College);Heavy Metal Level Detection and Analysis of Water,Mash and Raw Milk in Different Scale Dairy Farms in Yining City[J];Modern Agricultural Science and Technology;2011-16
5 ZHU Yu zhuo 1,PANG Hui min 1, XING Shen yang 2, GAO Jiu chun 3,XU Yun jing △ (1. Dept.of Medical Genetics,School of Basic Medical Sciences, Jilin University, Changchun 130021, China; 2.Dept.of Biology,Colloge of Nursing,Jilin University; 3. Dept.of Cytobiology,School of Basic Medical Sciences,Jlin University);Inhibitory Effect of Pulsatilla Chinensis Regel on Sperm Abnormalities Induced by CdSO_4 in Mice[J];Journal of Jilin University of (Medicine Edition);2003-04
6 ZHOU Yong, JIN Hui-Ying,FENG Wei-Hua, HU Hui-Min, ZHENG Zun, YIN Mu-Quan(1. Department of Biochemistry and Molecular Biology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China; 2. Department of Cell Biology; 3. Depar;Oxidative injury mechanism of acute cadmium-exposed rat testis[J];Academic Journal of Second Military Medical University;2002-01
7 LIU Feng-jun,XU Peng-peng,YANG Zi-jun,HE Jia-shuang,MA De-gang,LE Qiang (Animal Science and Technology College,Henan University of Science and Technology,Luoyang,Henan,471003,China);Pathohistological Changes on Experimental Cadmium Poisoning in Mice[J];Progress in Veterinary Medicine;2008-12
8 JIANG Yan-qiong1,WANG Jia-yue1,TANG Si-xian1,LU Yi-wei1,HAO Jia2 (1.School of Life Science,East China Normal University,Shanghai 200062,China;2.Fishery Technical Extension Center,Dalian 116021,China);Toxicity Effect of Cadmium on the Testicular Tissue of Coturnix coturnix japonica[J];Journal of Fudan University(Natural Science);2007-06
9 Hua Ping,Su Min,Xu Tingliang,Jiang Fengrong. Department of Histology and Embryology,Guiyang Medical College,Guiyang 550004 China;A morphological study on the protective effect of Vitamin E on the spermatogenic cells of mice exposed cadmium chronically.[J];Anatomy Research;2004-04
10 SU Min,HUANG Yue,XU Ting-liang,JIANG Feng-rong. Department of Histology and Embryology,Guiyang Medical University,Guiyang 550004 China;Influence Vitamin E on ultrastucture of filtration barrier of glomeruli with chronically cadmium-exposed[J];Anatomy Research;2008-04
China Proceedings of conference Full-text Database 5 Hits
1 WEI Qiang,YUAN Hui~* (College of Veterinary Medicine,Hunan Agricultural University,Changsha Hunan 410128, China);Research progress of Reproductive Toxicity of Cadmium on Male Animal[A];[C];2011
2 CAO Jian-ping,WANG Wen-xiang,LIAO Hui-zhen,et al.Department of Nutrition and Health Care,Institute of Public Health,Fujian Medical University.(Fuzhou 350004,China);Effects of Subchronic Cadmium Exposure on Male Reproductive Ability in Rats.[A];[C];2004
3 JIANG Yan-qiong~1 WANG Jia-yue~1 TANG Si-xian~1 LU Yi-wei~1 HAO Jia~2 (1.School of Life Science,East China Normal University,Shanghai 200062,China; 2.Fishery Technical Extension Center,Dalian 116021,China);Toxicity Effect of Cadmium on the Testicular Tissue of Coturnix coturnix japonica[A];[C];2008
4 Li Honglei Fang Huiling Wang Xiaoli Tan Chengming Zhang Ling (College of Animal Science and Technology,Guangxi University,Nanning 530005,China);Effect of fluoride and protection of zinc on apoptosis of spermatogenic cells of mouse[A];[C];2008
5 CHEN Min, XIE Ji-min, SONG Xia, LI Min-zhi School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013;Comparative Effects of Five Chelating Agents on Testicular Toxicity in Mice Induced by Acute Exposure to Cadmium[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 JIN Long_jin,LOU Zhe_feng,DONG Jie_ying,et al (Central Laboratory of Biology,Wenzhou Medical Collage,Wenzhou325027,China);Effects of Cadmium and Mercury on DNA Damage of Mice Bone Marrow Cell and Testicle Germ Cell in vitro[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-02
2 CAO Yu-jing et al(State Environmental Protection Key Laboratory for Lake Pollution Control,Chinese Research Academy of Environmental Sciences,Beijing 100012);Establishment of Water Quality Criteria for Cadmium in Freshwater[J];Journal of Anhui Agricultural Sciences;2010-03
3 SONG Zhi-hui et al(College of Environment and Safety Engineering,Qingdao Technological University,Qingdao,Shandong 266042);Study on Toxic Effects of Cu and Cd on Ceratophyllum demersum L.[J];Journal of Anhui Agricultural Sciences;2010-07
4 WANG Lan ①** SUN Hai Feng ② LI Chun Yuan ③ (① College of Life Science and Technology, Shanxi University, Taiyuan 030006, Shanxi, China) (② Collleg of Chemistry Engineering, Shanxi University, Taiyuan 030006, Shanxi, China) (③ Ch;EFFECTS OF CADMIUM ON SPERMATOGENESIS IN FRESHWATER CRAB (SINOPOTAMON YANGTSEKIENSE)~*[J];Acta Zoologica Sinica;2002-05
5 YAN Bo, WANG Lan , LI Yong-Quan, LIU Na, WANG QianCollege of Life Science and Technology, Shanxi University, Taiyuan 030006, China;Effects of cadmium on hepatopancreatic antioxidant enzyme activity in a freshwater crab Sinopotamon yangtsekiense[J];Acta Zoologica Sinica;2007-06
6 WU Hai yan,DU Bao dong,NIU Chun bo,WANG Ping,JIN Xin (Dept.of Otorhinilaryngology,The First Hospital,Jilin University,Changchun 130021 China);The effects of the decreased activity of COX on rat cochlear with presbyacusis[J];Journal of Norman Bethune University of Medical Science;2002-01
7 ZHANG Cui1,2,ZHAI Yu-xiu1,2,NING Jin-song2,3,SHANG De-rong2,3,WANG Jia-lin3(1.Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Ministry of Agriculture;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China;2.National Center for Quality Supervision and Test of Fishery Products,Qingdao 266071,China;3.Ocean University of China,Qingdao 266003,China);A Review: Research on Cadmium in Aquatic Animals[J];Fisheries Science;2007-08
8 TU Xian-gan, LAI Tang, ZHENG Ke-li,et al. Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080,China;A Study on Apoptosis and Expression of Fas, bax and bcl-2 Proteins in Testicular Carcinoma[J];Journal of Chinese Physician;2005-01
9 ZHOU Yong, JIN Hui-Ying,FENG Wei-Hua, HU Hui-Min, ZHENG Zun, YIN Mu-Quan(1. Department of Biochemistry and Molecular Biology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China; 2. Department of Cell Biology; 3. Depar;Oxidative injury mechanism of acute cadmium-exposed rat testis[J];Academic Journal of Second Military Medical University;2002-01
10 LIU Wen-wu,SUN Xue-jun~(*),XU Wei-gang(Department of Diving Medicine,Faculty of Navy Medicine,Second Military Medical University,Shanghai 200433,China);Mitochondrial nitric oxide synthase: biological function[J];Academic Journal of Second Military Medical University;2006-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LOU Zhe-feng1,GUAN Min-qiang2,CHEN Zhong-yi3, CAO Qiong-jie3,RUAN Dong-fen3,JIN Long-jin3,(1.Central Laboratory of Biology;2.Laboratory Animal Center;3.College of Life Sciences,Wenzhou Medical College,Wenzhou 325027,Zhejiang,China);Effects of Cadmium Chloride on Index and mtATPase6 and D-Loop Mutations of Mice Testicle[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-06
2 HUANG Min-yi,CHENG Xiao-feng,LIU Mei-ling,YANG Guo-ying(Department of Life Science,Anqing Teachers College,Anqing,Anhui,246011,China);Advance in Toxic Effects of Cadmium in Male Animal Reproduction Function[J];Progress in Veterinary Medicine;2008-09
3 LI Ya-Lin;HUI Liang-Liang;College of Chemistry and Life Science, Weinan Normal University;;Damage of Testis by Carbon Tetrachloride Combining with Diethylnitrosamine in Mice[J];Chinese Journal of Zoology;2015-02
4 WANG Sui-xin,ZHANG Yu-hua,LI Xiang-yang,et al.Langfang Health Vocational College,Langfang,Hebei 065000,China;Research Advances of Toxicity of Heavy Metals to Spermatogenic Cell Correlated[J];Journal of Environment and Health;2011-04
5 GUO Shu-bang,LIU Li-qing,LU Tao-sheng,DAI Ai-ying,etc.Heze Medical College,Heze Shandong 274000,China.;The Experimental Research of the PoisonousEffects of Cadmium on the Reproduction of Male Rats[J];Henan Journal of Preventive Medicine;2010-04
6 WANG Xiao-kang1, CAI Ya-fei1,ZHANG Kai1, FAN Rui1, LI Jian-guo1, WU Guo-liang1, WANG Gen-lin2 (1.Anhui Normal University a.Provincial Key Laboratory of Conservation and Employment of Biological Resources; b.Key Laboratory of Biotic Environment and Ecological Safety in Anhui Province, Wuhu 241000, Anhui, China;2.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China);Apoptosis Induced by Cadmium and the Expression of Caspase-3,Bcl-2 and Bax mRNA in Testis of Mouse[J];Acta Laser Biology Sinica;2008-05
7 CAO Qiong-jie,CHEN Zhong-yi,RUAN Dong-fen,WANG Xin-zhen,LOU Zhe-feng,SHAO Wei-wei,JIN Long-jin(College of Life Sciences,Wenzhou Medical College,Key Research Laboratory for Medical Genetics of Zhejiang,Wenzhou,Zhejiang 325035,China);Effects of Cadmium Chloride on Organ Weight Coefficient and Mitochondrial D-Loop Point Mutation of Mouse Testicle[J];Journal of Environmental & Occupational Medicine;2010-11
8 LIU Jianbo, PAN Deng, JIANG Anna, HUANG Xiaoliang, YING Xueping* College of Life and Environmental Science, Wenzhou University, Wenzhou 325035;Effects of cadmium exposure on spermatozoon of Meretrix meretrix[J];Acta Scientiae Circumstantiae;2013-07
9 BIN Bin;LU Haiwang;WANG Jie;WANG Desheng;XU Jiexin;QIN Zhibiao;CUI Jinzhu;LIANG Jingsong;PANG Qiuhua;The First Affiliated Hospital of Guangxi University of Chinese Medicine;;Overview on Studies of Relevant Factors Affecting Ultrastructure of Testicular Epididymis and Sperm[J];Liaoning Journal of Traditional Chinese Medicine;2013-11
10 WANG Mei;XU Ying;FENG Le;CHEN Man-xia;YAN Wu-li;YANG Bing-yi;School of Public Health,Guangdong Pharmaceutical University,Guangdong Key Laboratory of Molecular Epidemiology;;Optimization for determination of cadmium in testis of mouse by graphite furnace atomic absorption spectrometry with central composite design-response surface[J];Journal of Environment and Health;2014-01
China Proceedings of conference Full-text Database 1 Hits
1 WEI Qiang,YUAN Hui~* (College of Veterinary Medicine,Hunan Agricultural University,Changsha Hunan 410128, China);Research progress of Reproductive Toxicity of Cadmium on Male Animal[A];[C];2011
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Jisheng, Xu Pengxiao, He Zhi. Department of Anatomy, Chinese People′s Armed Police Force Medical College, Tianjin 300162;Effect of zinc deficiency on apoptosis of spermatogenic cells of rat tostis[J];NATIONAL MEDICAL JOURNAL OF CHINA;1998-02
2 Hao Enzhu,et al.,(Binzhou Medical College Binzhou 256603);Study on Effect of Ethylene Oxide on Rats Spermatozoon[J];;1996-04
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