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《Chinese Journal of Andrology》 2004-06
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Efficacy and safety of Sertraline, Viagra and Cardura in patients with premature ejaculation

Tang Wenhao, Ma Lulin, Zhao Lianming, Liu Yuqing The Urology Department of Peking University Third hospital Beijng, 10083, China Chen Zhenwen The National Research Institute for Family Planning, Beijing, 100081  
Objective To compare the efficacy of Sertraline, Viagra and Cardura for the treatment of premature ejaculation (PE). Methods 120 PE patients were divided into four groups randomly: control group (only behavior therapy group), Cardura with behavior group, Viagra with behavior group and Sertraline with behavior group. Intra-vaginal ejaculation latency time (IELT) was recorded before and after treatment and also the coitus satisfaction degree of patient and partner. Results Before treatment, the IELT of four groups are (0.8000±0.1983)min, (0.8933±0.3216)min, (0.7333±0.2397)min and (0.8500±0.2910)min respectively; after treatment, the IELT are (1.8200±0.5413 )min, (2.6467±0.6726)min, (3.6333±0.5542)min and (4.8533±0.571) min respectively. In the face of satisfaction degree, Sertraline is better than Viagra, Viagra is better than Cardura and Cardura better than behavior. Conclusion For treating PE, Sertraline is the best during the clinical trial and may be the first choice for the pharmacotherapy of PE. If PE patient simultaneously has erectile dysfunction, Viagra may be used; if PE patient has simultaneously benign prostate hyperplasia, Cardura may be used. However, the clinical material of the efficacy of Viagra and Cardura for PE treatment is little, more research work should be done.
【CateGory Index】: R698.1
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