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《Chinese Journal of Andrology》 2009-08
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Expression of IGF-1 in non-obstructive azoospermia testicle tissue

Wang Haiyan,Liu Ziting,Luo Chao Department of Urology,the second Xiangya Hospital of Centralsouth University,Changsha,Hunan 410011,China  
Objective To investigate the relationship between expression of IGF-1 in human testicle tissue and non-obstructive azoospermia.Methods The expression of IGF-1 in testicle tissue of 32 non -obstructive azoospermia patients and 13 normal testicle tissue were detected by immunohistochemistry.The expression patterns of IGF-1 on the area and density of staining were comparatively analyzed using statistics methods.Results HE staining analysis showed naught or few amounts of zoosperm,seminiferous epithelium exuviation,arrangement disorder and spermatogenic cell atrophy in seminiferous tubules of the human non-obstructive azoospermia testicle tissue,The positive expression rate of IGF-1 in non-obstructive azoospermia testicle tissue was 12.5%,while in normal testicle tissue was 76.92%(P0.01).Conclusion(1) Downregulated expression of IGF-1 in testicle tissue might be closely associated with spermatogenic dysfunction;(2)The pathological changes such as seminiferous epithelium exuviations,arrangement disorder and dyszoospermia were discovered in seminiferous tubules of the non-obstructive azoospermia testicle tissue.
【CateGory Index】: R698.2
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