Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF ANDROLOGY》 1997-02
Add to Favorite Get Latest Update

Effect of T 4 and T 7 , compounds isolated from Tripterygium wilfordii, on the rates of chromosome aberration and micronuclei formation in spermatogenic cells of male rats

LIU Qilan, XU Ye, QIAN Shaozhen Jiangsu Family Planning Institute (Nanjing 210029)  
The present study was to investigate the effects of antifertility doses of T 4 and T 7 on the occurrence of chromosome aberration and micronuclei formation in spermatogenic cells of male SD rats. The rats were given orally either T 4 80 μg/kg·d -1 or T 7 317 μg/kg·d -1 for 10 weeks. After that the chromosome aberration and micronuclei rates were examined and compared with those of the control group. It was shown that there were no significant difference in these parameters between the two groups and between either group and the control ( P 0.05). However the data of T 7 were closer to those of the control. Results suggested that both T 4 and T 7 did not damage the genetic material, while T 7 might be better than T 4 in this respect.
【CateGory Index】: R-332
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 YANG Jian-yi,GAO Bao-zhen,LI Li,WANG Wen-juan,GUO Hong-gang,BIAN Si-cheng(Department of Biology,Shanxi Medical University,Taiyuan 030001,China);Reproductive Cell Toxicity of Glycosides of Tripterygium Wilfordii Hook.f on Male Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
2 Jian Wei ZHANG, Qi Lan LIU, Ning LIN, Ye XU, Shao Zhen QIAN (Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China);Effects of Chlorotriptolide and Triptonide on Chromosome Aberration and Micronuclei of Bone Marrow Cell in Male Rats[J];Acto andrologica Sinica;2002-06
3 CUI Rui-qin~1 DING Ying~2 ZHENG Gui-zhen~2 1 Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 2 Henan University of Traditional Chinese Medicine,Zhengzhou 450004,China;Procreant toxicity of Tripterygium wilfordii F and its active components[J];Chinese Journal of New Drugs;2008-11
【Citations】
Chinese Journal Full-text Database 7 Hits
1 J.F.Shi Y.Wang O.L.Liu L.Pan J.Q.Sun Z.T.Zhang Y.Z.Hu Y.Xu S.Z.Qian Jiangsu Family Planning Institute, Nanjing 210004;GENETIC STUDIES ON TRIPTERYGIUM WILFORDII AND AN ACTIVE COMPOUND ISOLATED FROM THE PLANT[J];Chinese Journal of Andrology;1989-03
2 LIU Qi-Lan, ZHANG Zi-Ning, ZHONG Chang-Qi,QIAN Shao zhen. Jiangsu Family Planning Institute, Nanjing 210029;EFFECT OF TRIPTERYGIUM WILFORDII ON SISTER CHROMATID EXCHANGE IN MOUSE[J];Chinese Journal of Andrology;1994-01
3 Zhang Zhong-shu (The Shanghai Institute of Planned Parenthood Research)Pan Xian-xin Wang Min-ming Yao Yu-long (Shanghai Research Institute of Pharmaceutical Industry);GENETIC STUDIES OF THE GOSSYPOL——Ⅰ.THE COMPARATIVE STUDIES OF CYTOGENETIC EFFECTS OF GOSSYPOL ACETATE ON MALE GERM CELLS AND LYMPHOCYTES IN BLOOD OF THE MICRONUCLEUS TEST IN RATS[J];Reproduction & Contraception;1981-01
4 Zhou Guangyun, Zhang Baozhen, Wang Zeyuan, Li QiyuanDepartment of Biology, Faculty of Basic Medical Science, Tongji Medical University, Wuhan;The Effect of Tripterygium Wilfordii to ChromosomeAberration of Mice[J];Acta Universitatis Medictnae Tangji;1987-04
5 Dai Wenping; Liu Ping;Han Yuhua;et al(Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005);The Effect of Tripterygium wilfordii Monomers T_4,T_7,T_(15)and Triptolide on Rat Nuclear Protein[J];ACTA ACADEMIAE MEDICINAE SINICAE;1994-01
6 Wang Xu Li Wen Zhou Rumin Cao Neng Liu Suqing (Department of Biology Yunnan Normal University,Kunming 650092);Measurement of Micronucleus Diameters as a Test for the Detection of Aneugens[J];Hereditas(Beijing);1993-03
7 LIU De-Yu,JIA Meng-Chun (National Research Institute for Family Planning,Beijing 100081);Effect of tripchlorolide on micronucleus induction in spermatogenic cells of rat[J];Chinese Journal of Pharmacology and Toxicology;1993-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Jian-yi,GAO Bao-zhen,LI Li,WANG Wen-juan,GUO Hong-gang,BIAN Si-cheng(Department of Biology,Shanxi Medical University,Taiyuan 030001,China);Reproductive Cell Toxicity of Glycosides of Tripterygium Wilfordii Hook.f on Male Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
2 Wang Xu,Liu Suqing,He Zhengji,Qiu YujieDepartment of Biology, Yunnan Normal University,Kunming 650092;ANTIKINETOCHORE ANTIBODY STAINING TO DISCRIMI-NATE BETWEEN TWO MICRONUCLEUS ORIGINS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1994-02
3 CAO Neng,AO Xin_yu,TANG Ji_hong,et al (College of Life Science,Yunnan Normal University,kunming650092,China);The Research of the Pueraria Edulia Pamp in Reducing the Mouse Bone Marrow Cell's Micronucleus Caused by Tobacco Tar[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-02
4 JIA Yue 1 ,CUI Yu_gui 2 ,WANG Xing_hai 3 ,et al (1.Endocriology Department,the First Affiliated Hospital of Nanjing Medical University,Nanjing210029,Chian;2.Key Lab,the First Affiliated Hospital of Nanjing Medical University,Nanjing210029,China;3.Jiangsu Family Planning Institute,Nanjing210034,China.);The Micronucleus Test of Meddroxyprogesterone Acetate in Bone Marroww Polychromatic Erythrocytes and Spermatogenic Cells of Malerats[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-02
5 Jian Wei ZHANG, Qi Lan LIU, Ning LIN, Ye XU, Shao Zhen QIAN (Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China);Effects of Chlorotriptolide and Triptonide on Chromosome Aberration and Micronuclei of Bone Marrow Cell in Male Rats[J];Acto andrologica Sinica;2002-06
6 LIU Qi-Lan, ZHANG Zi-Ning, ZHONG Chang-Qi,QIAN Shao zhen. Jiangsu Family Planning Institute, Nanjing 210029;EFFECT OF TRIPTERYGIUM WILFORDII ON SISTER CHROMATID EXCHANGE IN MOUSE[J];Chinese Journal of Andrology;1994-01
7 Liu Qi- lan et al. Jiansu Family planning Insituet,Nanjing,210029.;Effect of Bromo-Geramine(G-12)on Micronuclei of Polychromatophilic Erythroblasts in Mice.[J];Chinese Journal of Family Planning;1994-06
8 Chen Jinhua Zhou Li Gao Hepin Fang Ronghua(Xiaogan Teachers College of Hubei 432100);Preliminary study on induction of chromosomal structure variation in pepper by treatment colchicine[J];HUBEI AGRICULTURAL SCIENCES;1995-06
9 Wan Jianyu Hu Lian Duan Yonggang The Family Planning Institute of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;The Expression of Binl-b Protein and mRNA in the Epididymis of Oligoasthenozoospermia Rat Models[J];Chinese Journal of Family Planning;2008-08
10 Qu Jiying,Su Qichang,Xu Chongyang Scientific ressareh institute of family planning of shandong province(Jinang 250020);Analysis of blood potassium before and after administration of low doses acetic gossypol[J];Chinese Journal of andrology;2001-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Hao Li,Lu Wen,Zhao Min,et al Department of Nephrology First Affiliated Hospital,Anhui Medical University,Hefei 230022;The protective effect to ovary by the usage combined with hormone replacement therapy in the patients with Triptergium wifordii[J];Anhui Medical Journal;2007-01
2 LIU Ming-xing, DONG Jing, YANG Ya-jiang~*, YANG Xiang-liang , XU Hui-bi (The Research Institute of Pharmaceutics, Huazhong University of Science and Technology, Wuhan 430074);RP-HPLC Determination of Encapsulation Efficiency and Drug Loading of Triptolide-Loaded Poly(D,L-lactic acid) Nanoparticles[J];Journal of Analytical Science;2004-05
3 Zhou Hong, Zhou Xinhua, Wu Wei, Zhang Quan, Ding Chengying (Department of Anatomy, Medicine School, Wuhan University, Wuhan 430071, China);APOPTOSIS OF GERM CELLS IN RAT TESTIS DURING FETAL AND POSTNATAL DEVELOPMENT[J];Chinese Journal of Histochemistry and Cytochemistry;2002-02
4 LU Jing ,ZHAO Lijuan,Kasama T,et al. Division of Rheumatology,First Clinical College,China Medical University,Shenyang 110001,China;Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis[J];Chinese Journal of Rheumatology;2001-05
5 DING Xiao ping,YAN Su wen,ZHANG Ning,et al (Research Center for Bearing & Rearing Better Children,202 Hospital,Shenyang 110003 China);Effect of Short-wave Radiation on Male Reproductive Function Evaluated by DNA Strand Breakage Analysis[J];Industrial Health and Occupational Diseases;2002-02
6 QIU Liang\|miao, PENG Wen\|fu, CHEN Yu\|mei, LIN Jian\|zhen (Institute of Plant Protection ,Fujian Academy of Agricultural Sciences, Fuzhou, Fujian\ 350013, China);Antifertility effects of Glycosides of Tripterygium wilfordii on male farmland rats and mice[J];Fujian Journal of Agricultural Sciences;2001-04
7 Zou Xiaoming; Lin Wen; Fang Xiangdong; Li Quanqi; Li Jinsheng; Wang Xiaoning(Departments of Cardiothoracic Surgery and Laborary , Nanfang Hospital; Institute of Molecular Immunology, First MilitaryMedical University, Guangzhou, 510515);Effect of Triptolide on cardiac allograft survival in mice[J];Journal of First Military Medical University;1999-01
8 Lin Yakang(Shanghai Institute of Cell Biology, Academia Sinica, Shanghai 200031);Studies of Synaptonemal Complex Karyotype and their Length Changes during Pachytene in Mouse Spermatocytes[J];JOURNAL OF CHINESE ELECTRON MICROSCOPY SOCIETY;1995-02
9 ZHOU Ji ping, ZHANG Zhou ping, Hu Yong, QIU Gui fang(Academy of Animal Husbandry and veterinary Science in Qinghai Province, Xining, Qinghai, 810003, China);Relationship between Meiosis and Male Sterility of Yak Outbreeding Progeny[J];JOURNAL OF YELLOW CATTLE SCIENCE;1999-05
10 LIU Jing yu 1,2 , ZENG Qing hua 1, BAI Ling 2, LI Shuo ping 2, HAO Shui 1 (1.Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China; 2.Department of Bioengineering, Henan University, Kaifeng 475001, China);Analysis about synaptonemal complexes in Chinese foetal oocytes[J];Journal of Northeast Normal University (Natural Science Edition);2001-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 YANG Jian-yi,GAO Bao-zhen,LI Li,WANG Wen-juan,GUO Hong-gang,BIAN Si-cheng(Department of Biology,Shanxi Medical University,Taiyuan 030001,China);Reproductive Cell Toxicity of Glycosides of Tripterygium Wilfordii Hook.f on Male Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
2 Wang Huili, Yang Yejin, He Wei et al. Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030;Effect of triptolide on cytotoxicity and NO production of activated mouse peritoneal macrophage.[J];Central China Medical Journal;2003-05
3 He Wei, Pan Jianqing, Zeng Ye et al Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030;Effect of Triptonide on Secretion of NO and TNF-α in Mouse Peritoneal Macrophages[J];Acta Universitatis Medictnae Tangji;2005-02
4 ZHENG Xiao-juan,LIU Xia(Henan University of Chinese Medicine,Zhengzhou Henan 450008);Comparison of Efficacies on Prevention from Renal Damage of Henoch-Schonlein Purpura Treated with Tripterygium Wilfordii Polyglycoside Tablets of Different Doses[J];World Journal of Integrated Traditional and Western Medicine;2009-03
5 LV Li-ping,WAN Jun-mei,WANG Feng-juan (Hubei Academy of Traditional Chinese Medicine and Pharmacy,Hubei Wuhan 430074,China);Effect of triptonide on inflammation and immunity function[J];Chinese Journal of Hospital Pharmacy;2006-06
6 ;Effect of polyglycoside of Trip terygium wilfordi Hook.f.on cytotoxicity and NO Production in activated peritoneal elicited macrophage of mice[J];Study Journal of Traditional Chinese Medicine;2004-11
7 WANG Hui-li WANG Shaojuan YANG Ye-jin Department of Biochemistry and Molecular Biology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan(430030);Effect of Triptofide on NO Released by Activated Peritoneal Macrophages in Mice[J];Chinese Journal of Integrated Traditional and Western Medicine;2004-S1
8 DONG Chen, JIAO Yu-qing, LU Si-guang (Department of Pediatrics, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China);The use of double-dosed tripterygium polyglucoside in treating Henoch-Schonlein purpura[J];Acta Academiae Medicinae Xuzhou;2003-04
9 LI Xiangchu HE Kiaofei LI Junhua (Department of Gastroenterology,The Affiliated Hospital of Xianning Medical College,Xianning 430071);Effects of tripterygium polyglycoside on expression of TNF-αand ICAM-1 in rats model of colitis[J];Chinese Journal of Chronic Diseases;2005-02
10 LI Jun hua 1, HE Xiao fei 2, YU Jie ping 1 (1. People’s Hospital of Wuhan University, Wuhan 430060, Hubei, China; 2. Affiliated Hospital of Xianning Medical College, Xianning 430071,Hubei, China );Protective effect of tripterygium wilfordii polyglycosidium on ulcerative colitis model rats[J];Modern Jorunal of Integrated Traditional Chinese and Western Medicine;2003-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SHI LIMING WANG JIANHUA ZHANG XIRAN CHEN YUTSE(Kunming Institute of Zoology,Academia Sinica);A NEW PROCEDURE FOR THE EVALUATION OF RADIOPROTECTORS BY CYTOGENETIC METHOD 1.STUDIES OF THE MICRONUCLEI OF BONE MARROW IN MICE AS AN INDICATOR FOR THE SCREENING OF RADIOPROTECTIVE DRUGS[J];Acta Zoologica Sinica;1979-03
2 J.F.Shi Y.Wang O.L.Liu L.Pan J.Q.Sun Z.T.Zhang Y.Z.Hu Y.Xu S.Z.Qian Jiangsu Family Planning Institute, Nanjing 210004;GENETIC STUDIES ON TRIPTERYGIUM WILFORDII AND AN ACTIVE COMPOUND ISOLATED FROM THE PLANT[J];Chinese Journal of Andrology;1989-03
3 S.Z. Qian, Y.Xu, Y, Wang, Z.T.Zhang, N.Lin, S.M.Wang, A.P.Qi,Jiangsu Family Planning Institute, Nanjing 210004, China Z.P Gu, Y.E.Wang, Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China;SCREENING AND PHARMACODYNAMIC STUDY OF MALE ANTIFERTILITY COMPOUNDS ISOLATED FROM TRIPTERYGIUM WILFORDII[J];Chinese Journal of Andrology;1989-04
4 Liu Qi- lan et al. Jiansu Family planning Insituet,Nanjing,210029.;Effect of Bromo-Geramine(G-12)on Micronuclei of Polychromatophilic Erythroblasts in Mice.[J];Chinese Journal of Family Planning;1994-06
5 Wang Yi-xin;Chen Zhen-xing Department of male contraceptive research of Ren Ji Hospital, Shanghai Second Medical University;A Possible Mechanism of Gossypol-Induced Hypokalemia and Its Relation to Gossypol Dose[J];Reproduction and Contraception;1991-02
6 KO YI-BAO LIN XIN-KAI LIN XIU-YUAN (Shanghai institute of Cell Biology,Academia Sinica) CHANG YUE-HUA (Shanghai institute of pharmaceutical industry) MAR YU-ZHEN YU SU-ER DIN YONG (Shanghai Cereals,Oils Corporation of Industry);STUDIES ON THE ANTIFERTILITY EFFECT OF GOSSYPOL Ⅲ.THE DETERMINATION OF THE QUANTITIES OF GOSSYPOL IN BLOOD AND RELATED INTERNAL ORGANS AFTER ADMINISTRATION OF THE DRUG IN RATS[J];Acta Biologiae Experimentalis Sinica;1979-01
7 Zhou Wen-yu Xue She-pu (Department of Cell Biology,Institute of Basic Medical Research,Chinese Acdemy of Medical Sciences);EFFECT OF GOSSYPOL ACETATE ON THE DNA CONTENT OF PRIMARY SPERMATOCYTES IN RAT[J];Reproduction & Contraception;1981-03
8 Dai Rong-xi;Pang Shih-nee;Lin Xin-kai;Ke Yi-bao;Liu Zhen-lian;Dong Rong-hua Shanghai Institute of Cell Biology, Academia Sinica;A STUDY OF ANTIFERTILITY OF COTTONSEED[J];Acta Biologiae Experimentalis Sinica;1978-01
9 Zhou Guangyun, Zhang Baozhen, Wang Zeyuan, Li QiyuanDepartment of Biology, Faculty of Basic Medical Science, Tongji Medical University, Wuhan;The Effect of Tripterygium Wilfordii to ChromosomeAberration of Mice[J];Acta Universitatis Medictnae Tangji;1987-04
10 Zheng Jiarun, Fang Jialin, Gu Kexian, Xu Lanfang, Gao Jiwei, Guo Hongzhi, Yu Yanhua and Sun Huizhen(Institute of Dermatology, Nanjing);Screening of Active Anti-inflammatory-immuno-suppressive and Antifertile Compositions from Tripterygium wilfordii Ⅰ. Screening of 8 Components from Total Glucosides of Tripterygium wilfordii (TⅡ)[J];Acta Academiae Medicinae Sinicae;1987-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved