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《Chinese Journal of Pesticide Science》 2010-04
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Design,synthesis and fungicidal activity of coumoxystrobin(SYP-3375)

LI Miao, LIU Chang-ling, ZHANG Ming-xing, GUAN Ai-ying, ZHANG Hong, SI Nai-guo (State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co.,Ltd.,Shenyang 110021,China)  
The discovery,synthesis,fungicidal activity,toxicological properties of(E)-methyl 2-[2-(3-n-butyl-4-methyl-2-oxo-chromen-7-yloxy) methyl phenyl]-3-methoxyacrylate(coumoxystrobin,SYP-3375) were introduced.Coumoxystrobin was synthesized from ethyl acetoacetate as starting material via several steps including alkylation,cyclization and condensation.The structures of coumoxystrobin and the intermediates were identified by nuclear magnetic resonance(1H NMR),IR and elemental analysis.The bioactivity results showed that in greenhouse conditions coumoxystrobin had lower activity in controlling cucumber downy mildew and powdery mildew than contrasts,in field trials,the fungicidal activity against cucumber downy mildew of coumoxystrobin at 100 g(a.i)/ha was almost equivalent to that of enestroburin and azoxystrobin,the fungicidal activity against cucumber powdery mildew at 50 and 200 g (a.i)/ha was lower or equivalent to that of enestroburin EC.
【Fund】: “十一五”国家科技支撑计划项目(2006BAE01A03-2);; 国家重点基础研究发展计划(973计划)项目(2003CB114400 2010CB126105)
【CateGory Index】: TQ450.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Liu Changling 1,2,Zhong Bin1,Li Zhengming1 (1 Nankai University,Tianjin 300071,China; 2 Shenyang Research Institute of Chemical Industry,Shenyang 110021,China);Agrochemicals Discovered and Developed from Natural Leads(II)——Insecticides and Acaricide[J];Pesticides;2003-12
2 CHEN Liang1,2, LIU Jun-li1, SI Nai-guo1, ZHANG Li-qun2, SUN Yong-ji3, LIN Wen-zhong4 (1. Shenyang Research Institute of Chemical Industry, Shenyang 110021, China; 2.China Agriculture University, Beijing 100094,China; 3.Jilin Province Bada Pesticide Co., Ltd., Gongzhuling 136100, Jilin, China;4.The Station of Plant Protection of Pulandian, Dalian 116300, Liaoning, China);Efficacy of SYP-3375 against Apple Valsa Canker[J];Agrochemicals;2009-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Chang-ling (Shenyang Research Institute of Chemical Industry, Shenyang 110021, China);Agrochemicals Developed from Natural Product-based Precursors[J];Fine and Specialty Chemicals;2004-06
2 Zhang Guosheng(Shenyang Research Institute of Chemical Industry,Shenyang 110021);Current Status of Application , Development and Prospect of Strobin Fungicides[J];Pesticide Science and Administration;2003-12
3 LING Li-zhi~(1,2),LIU Ai-ping~2,CHEN Can~2,WEI Zhen-zhong~(2,3), WANG Sheng-de~2,YIN Du-lin~1,WANG Xiao-guang~(2*) (1.College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China; 2.Hunan Branch of National Pesticide R & D South Center,Hunan Research Institute of Chemical Industry,Changsha 410007,China;3.College of Chemistry,Central China Normal University,Wuhan 430079,China);Synthesis and Biological Activity of Oxime Ethers Containing Indanone[J];Chinese Journal of Pesticide Science;2006-01
4 YAN Xiao-jing,JIN Shu-hui,CHEN Fu-heng,WANG Dao-quan~* (Key Laboratory of Pesticide Chemistry and Application Technology,Department of Applied Chemistry,China Agricultural University,Beijing 100094,China);Advance in Research of the Target of Action of Strobilurin Fungicides[J];Chinese Journal of Pesticide Science;2006-04
5 JIA Bian-tao (College of Agriculture,Shanxi Agricultural University,Shanxi Taigu 030801,China);Progress in the Study on the Action Mechanism and Insecticide Resistance of Bishydrazide Insect Growth Regulator[J];Modern Agrochemicals;2008-04
6 Liu Changling 1,2 ,Li Zhengming 1 (1 Nankai University, Tianjin 300071,China; 2 Shenyang Research Institute of Chemical Industry, Shenyang 110021,China);Agrochemicals Discovered and Developed from Natural Leads(I)—— Fungicides[J];Pesticides;2003-11
7 FAN Wen-Yu1, MA Yun-Sheng2, WANG Wei3(1Shenyang Chemical and Engeer Institute, Shenyang 110021, China; 2 Shandong Jing-bo Group, Boxing 256505, China; 3JiamusiEntry-Exit Inspection and Quarantine Bureau of the People Republic of China, Jiamusi 154002, China);A New Fungicide Picoxystrobin[J];Pesticides;2005-06
8 ZHANG Ming-Xing, LIU Chang-Ling, ZHANG Hong(Shenyang Research Institute of Chemical Industry, Shenyang 110021, China);A Novel Insecticide and Acaricide:Spiromesifen[J];Pesticides;2005-12
9 TU Song1,XU Long-he1,2,YU Chun-rui1,2,ZHANG Hong,LI Zhi-nian2,LIU Chang-bo3(1.State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116012,Liaoning,China;2.Shenyang Research Institute of Chemical Industry,Shenyang 110021,China;3.The School PharmaceuticalEngineering,Shenyang Pharmaceutical University,Shenyang 110016,China);Synthesis of novel indene-substituted oxime ether compounds[J];Agrochemicals;2006-10
10 YANG Ji-chun1, WU Qiao1,2, LIU Ruo-lin3, MA Shi-chun1,2, LIU Chang-ling1 (1.Shenyang Research Institute of Chemical Industry, Shenyang 110021, China; 2.Shenyang Institute of Chemical Technology, Shenyang 110142, China; 3.College of Chemistry, Liaoning University, Shenyang 110036, China);Recent Advances on the Development of Agricultural Fungicides[J];Agrochemicals;2008-06
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 XU Shang cheng *, JIANG Mu geng (1 Jiangsu Pesticide Research Institute, Nanjing 210036, China; 2 College of Sciences, Nanjing Agricultural University, Nanjing 210095,China);Advances in the Research of Pyrrole Compoundswith Pesticidal Activities[J];Chinese Journal of Pesticide Science;2002-02
2 Xu Shangcheng et al.(Jiangsu Pesticide Research Institute,Nanjing 210036);Research & Development of Chlorfenapyr[J];Pesticides;2003-02
3 Liu Changling (Shenyang Research Institute of Chemical Industry,Shenyang 110021,China);Recent Advance on Discovered and Developed Insecticide and Acaricide[J];Pesticides;2003-10
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