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《Agrochemicals》 2007-06
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Antiviral Activity of Antofine from Cynanchum komarovii

WANG Qing-min1,YAO Yu-cheng2,HUANG Run-qiu1,FAN Zhi-jin1,LI Guang-ren1,YU Xue-shun2 (1.State Key Laboratory of Elemento-Organic Chemistry,Research Institute of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China; 2.Inner Mongolia Polytechnic University,Huhehaote 010062,China)  
With the aim of searching antiviral substances to tobacco mosaic virus (TMV),we have found that alkaloid extracts from Cynanchum komarovii wildly distributed in the northwest part of the People's Republic of China show excellent antiviral activity against TMV. Using a bioassay directed fractionation approach,we have found that antofine is present as the primary content of the alkaloid. The results using a half-leaf method indicate that antofine has 60% inhibitory activity even at the concentration of 1 mg/L. Moreover,antofine exhibits excellent in vivo curative efficacies against TMV and PVY,for example,antofine shows 75% and 80% in vivo inhibition respectively at the concentration of 9 mg/L. Field experiments indicate that antofine has significantly better anti-TMV activities than ningnanmycin and virus A,and shows no crop phytotoxicity.
【Key Words】： Cynanchum komarovii antofine tobacco mosaic virus antiviral activity
【Fund】： 国家重点基础研究发展规划项目(2003CB114404);; 国家自然科学基金(20472039 20421202);; 新世纪优秀人才支持计划(NCET-04-0228);; 教育部科学技术研究重点项目(106046);; 国家“十五”科技攻关项目(2004BA308A22-10)
【CateGory Index】： S482.2
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