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《Journal of Clinical Electroneurophysiology》 2007-06
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Study of Cortical threshold of Motor evoked potentials by transcranial magnetic stimulation for model rats with Parkinson disease

HUO Juan,WANG Wei,SUN Lijun,et alDept of Neurology,Affiliated Hospital of Inner Mongolia Medical College,Huhhot(024000),China  
Objective:To make clear if Parkinson disease(PD)has cortical threshold(Ct)of transcranial magnetic stimulation-motor evoked potential(TMS-MEP)abnormality and if Ct changes with the developing state of illness.Methods:Rats were randomly assigned into either the experimental group(n=28)or the control group(n=12).The operated target was selected in right substantia nigra pars compacta(SNC)and ventra tegmental area(VTA).SNC and VTA were injected each 2μl(4μg /μl 6-OHDA in PBS)solution of 6-OHDA in the experimental group.Saline containing 2% vitamin C with isometry was injected to the same location in the control group.Examinating Ct before operation,a week and three weeks later after operation.Statistical analysis was done with SPSS 11.5 software.Results:A week after operation,Ct of left lower limb was significantly lowed in the experimental group(P0.05)as compared with the control group.In the experimental group,Ct of left lower limb significantly lower than that of the right(P0.05).Three weeks after operation,Ct of left lower limb was significantly lowed in the experimental group(P0.05)as compared with the control group,And Ct of left lower limb significantly lower than that of the right(P0.01).Conclusion:The worse the illness of PD model rats becomes,the longer in the course of disease is and the more the cortex excitability increases.
【CateGory Index】: R742.5
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