Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Electroneurophysiology》 2007-06
Add to Favorite Get Latest Update

Study of Cortical threshold of Motor evoked potentials by transcranial magnetic stimulation for model rats with Parkinson disease

HUO Juan,WANG Wei,SUN Lijun,et alDept of Neurology,Affiliated Hospital of Inner Mongolia Medical College,Huhhot(024000),China  
Objective:To make clear if Parkinson disease(PD)has cortical threshold(Ct)of transcranial magnetic stimulation-motor evoked potential(TMS-MEP)abnormality and if Ct changes with the developing state of illness.Methods:Rats were randomly assigned into either the experimental group(n=28)or the control group(n=12).The operated target was selected in right substantia nigra pars compacta(SNC)and ventra tegmental area(VTA).SNC and VTA were injected each 2μl(4μg /μl 6-OHDA in PBS)solution of 6-OHDA in the experimental group.Saline containing 2% vitamin C with isometry was injected to the same location in the control group.Examinating Ct before operation,a week and three weeks later after operation.Statistical analysis was done with SPSS 11.5 software.Results:A week after operation,Ct of left lower limb was significantly lowed in the experimental group(P0.05)as compared with the control group.In the experimental group,Ct of left lower limb significantly lower than that of the right(P0.05).Three weeks after operation,Ct of left lower limb was significantly lowed in the experimental group(P0.05)as compared with the control group,And Ct of left lower limb significantly lower than that of the right(P0.01).Conclusion:The worse the illness of PD model rats becomes,the longer in the course of disease is and the more the cortex excitability increases.
【CateGory Index】: R742.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Liu Qingrui,Duan Hongwei,Zhao Jing xia,Li Fengluan,Guo Liru,Depart-ment of Neurology,Fourth Affliated Hospital,Hebei Medical University,Shijiazhuang 050011,Hebei Province,China;The study in aged-dependent physiological threshold with the motor evoked potentials of transcranial magnetic stimulation[J];Modern Rehabilitation;2003-10
2 ZHOU Hou-guang ,LU Jian-ming,BAO Yuan-cheng,et al. The Department of Neurology,The 2nd Hospital of Changsu,Jiang shu 215500;The establishment and evaluation of 6-OHDA-lesioned rat model for parkinson's disease[J];Chinese Journal of Behavioral Medical Science;2002-01
Chinese Journal Full-text Database 10 Hits
1 SU Ping, LI Yan-hua, ZHENG Min, et al. Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Establishment of an improved rat model of Parkinson's disease[J];Guangdong Medical Journal;2006-07
2 ZHOU Hou-guang, BAO Yuan-cheng, LU Jian-ming. Department of Neurology,Affiliated Changshu Hospital, edical College of Yangzhou University, Changshu, Jiangshu 215500, China;Establishment of an improved rat model of Parkinson's disease[J];Foreign Medical Sciences Section On Neurology & Neurosurgery;2005-04
3 LU Jian-ming, ZHOU Hou-guang,BAO Yuan-cheng, et al. Department of Neurology, Affiliated Changshu Hospital of Medical College, Yangzhou University, Changshu 215500,China;Experimental study on cytotoxicity of levodopa in Parkinson's disease rat[J];Journal of Clinical Neurology;2004-05
4 Zhang Wei,Yang Hui.Department of Neurosurgery,Xinqiao Hospital,Third Military Medical University of PLA,Chongqing 400037,China;Establishment and Evaluation of Parkinson's disease model of rat with 6-OHDA[J];Sichuan Medical Journal;2007-08
5 Zhou Hou guang, Lu Jian ming,Bao Yuan cheng,Yang Zhi yong,You Nian xing Zhou Hou guang,Lu Jian ming,You Nian xing, Department of Neurology,Changshu Hospital, Medical College of Yangzhou University, Changshu 215500, Jiangsu Prov ince, China Bao Yuan cheng,Department of Neurology, First Affiliated Hospital, Anhui Coll ege of Traditional Chinese Medicine,Hefei 230031,Anhui Province, China Yang Zhi yong,Sun Yat sen University of Medical Sciences, Guangzhou 510001,G uangdong Province, China;Protective effect of reduced glutathione in treating rat model of Parkinson di sease combined with dementia[J];Chinese Journal of Clinical Rehabilitation;2005-01
6 KANG Jun-fang,ZHANG Bao-rong,YIN Hou-min,FENG Wei(Department of Neurology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China);Motor evoked potential in Parkinson's disease by transcranial magnetic stimulation[J];Chinese Journal of Pathophysiology;2009-04
7 ZHOU Hou-guang,BAO Yuan-cheng,LU Jian-ming,et al. (Department of Neurology,The Affiliated Changshu Hospital of Yangzhou University Medical College,Changshu 215500,China);The experimental study of glutathione on cyto-protection function in Parkinson disease rat[J];Journal of Apoplexy and Nervous Diseases;2005-03
8 TANG jun, XU Hai-wei, WU xuan, et al.Department of physiology, Third Military Medical University,Chongqing, 400038;An improved establishment of Parkinson's disease rat model and praxiology study on the Therapeutic transplantation of neural precursor cells[J];Chinese Journal of Behavioral Medical Science;2004-01
9 LU Jian-ming,ZHOU Hou-guang The Department of Neurology ,The Affiliated Changshu Hospital of Medical College of Yangzhou University Changshu 215500,China;The effects of levodopa on antioxidation function of parkinson disease rat[J];Chinese Journal of Behavioral Medical Science;2004-03
10 ZHOU Hou-gunag, BAO Yuan-cheng, LU Jian-ming, et al.The Department of Neurology, The Affiliated Changshu Hospital of Yangzhou University Medical College, Changshu 215500,China;The effect of glutathione on oxidation stress of Parkinson’s disease rat[J];Chinese Journal of Behavioral Medical Science;2004-03
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhou Mingfu;Zhang Hua;Wu Jinliang;Guo Zhangsheng;LinLing;Tang Shanjun;Zhou Xiangting(Department of Anatomy,Henan Medical University,Zhengzhou 450052);Establishment of animal model for Parkinson's disease[J];JOURNA OF HENAN MEDICAL UNIVERSITY;1994-04
2 Zhou Guoqin Zhou Xiaoda Li Ningli Shen Baiha Deprtment of Neurology, Renji Hospital, Shanghai Second Medical University.Shanghai 200001;A study on apoptosis in PC12 cell induced by 6-Hydroxydopamine[J];Journal of Brain and Nervous Diseases;1997-05
3 Shao Yanping (Department of Anatomy);Intracerebral Grafting of Neuronal Cell Suspensions Correct the Damage of Substantia Nigra Ⅰ. Animal Model[J];;1986-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved