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《Chinese Journal of Clinical Rational Drug Use》 2010-16
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Observation on effect of esomeprazole and omeprazole in treating chronic gastritis with positive helicobacter pylori

LIN Tu-kun,LONG Wei-dong,CHEN Chao-yang.The People's Hospital of Wuchuan,Wuchuan,Guangdong 525400,China  
Objective To investigate the effect and safety of esomeprazole and omeprazole in treating chronic gastritis with positive helicobacter pylori.Methods 58 cases with chronic gastritis with positive helicobacter pylori were divided into the observation group and the control group,all 28 cases.The observe group received the trigeminy treatment of esomeprazole and the control group received the trigeminy treatment of omeprazole,compared the efficacy and adverse reactions of these two groups.Results The total effective rate and clearance rate of Hp in observation group were 96.43% and 92.86% higher than 92.86% and 89.29% in control group,the difference was not statistically significant(P0.05).The disappearance rate of stomachache was 64.29% in observation group that higher than 32.14% in control group,the difference was statistically significant(P0.05).The side reaction rate was 7.14% in observation group that higher than 10.71% in control group,the difference was not statistically significant(P0.05).Conclusion The effect of esomeprazole in treating chronic gastritis with positive helicobacter pylori is same to that of and omeprazole,but the onset esomeprazole faster,to relieve symptoms more pronounced.
【CateGory Index】: R573.1
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